Carperitide acetate Atrial Natriuretic Peptide (ANP (1-28), human, porcine acetate)|cas:1366000-58-9|西域试剂

Carperitide acetate Atrial Natriuretic Peptide (ANP (1-28), human, porcine acetate),99.15%

产品编号：Bellancom-P1235A| CAS NO：1366000-58-9| 分子式：C₁₂₇H₂₀₃N₄₅O₃₉S₃.C₂H₄O₂| 分子量：3140.50

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货号	价格	库存与货期
Bellancom-P1235A	￥1800.00	杭州北京（现货）
Bellancom-P1235A	￥2800.00	杭州北京（现货）
Bellancom-P1235A	￥9800.00	杭州北京（现货）

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Carperitide acetate Atrial Natriuretic Peptide (ANP (1-28), human, porcine acetate)

产品介绍

Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) 是一种含 28 个氨基酸的激素，由心脏产生并分泌，以响应心脏损伤和机械拉伸。Carperitide acetate 抑制内皮素-1 (endothelin-1) 分泌。

生物活性

Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide acetate inhibits endothelin-1 secretion in a dose-dependent way.

体外研究

Atrial natriuretic peptide (ANP) is a diuretic, natriuretic, and vasodilatory peptide hormone originally isolated from mammalian hearts. In cultured porcine endothelial cells the inhibition by porcine ANP (1-28) of immunoreactive endothelin-1 secretion after stimulation with Angiotensin II (Ang II) is paralleled by an increase in the cellular cGMP level. Porcine ANP (1-28) strongly inhibits immunoreactive endothelin-1 secretion in porcine aorta after stimulation with Ang II. ANP is a cardiac hormone involved in electrolyte and fluid homeostasis. The inhibition by ANP of endothelin-1 secretion stimulated by angiotensin II (ANGII) and thrombin using cultured human umbilical-vein endothelial cells. Human ANP (1-28) inhibits immunoreactive (ir)-endothelin-1 secretion and increases cyclic GMP in the human umbilical-vein endothelial cells. In glomeruli from normal rats, Human ¹²⁵I-ANP (1-28) binds to a single population of high affinity receptors with a mean equilibrium dissociation constant of 0.46 nM. Human ANP (1-28) binds to the glomerular ANP receptor with high affinity stimulated cGMP accumulation. Human ANP (1-28) markedly stimulates cGMP generation, but not cAMP generation in normal rat glomeruli.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (15.92 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.3184 mL	1.5921 mL	3.1842 mL
5 mM	0.0637 mL	0.3184 mL	0.6368 mL
10 mM	0.0318 mL	0.1592 mL	0.3184 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture