BW 245C|cas:72814-32-5|西域试剂

BW 245C,99.14%

产品编号：Bellancom-101987| CAS NO：72814-32-5| 分子式：C₁₉H₃₂N₂O₅| 分子量：368.47

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-101987		￥3200.00	杭州北京（现货）
Bellancom-101987		￥9500.00	杭州北京（现货）

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BW 245C

产品介绍

BW 245C 是一种有效的前列腺素类DP受体prostanoid DP-receptor (DP1)激动剂，常用于中风等疾病的研究。

生物活性

BW 245C is a prostanoid DP-receptor (DP1) agonist, used to treat stroke.

体外研究

BW245C (0.01-1 μM) suppresses TGF-β-induced collagen secretion in a dose-dependent manner in Th2 cells. BW245C (0.01-1 μM) also increases intracellular cAMP in lung fibroblasts. BW245C (0.1-3 μmol/L) dose-dependently increases transendothelial electrical resistance and decreases the FITC-dextran permeability of human umbilical vein endothelial cells. BW245C (0.3 μmol/L) increases the intracellular cAMP level and subsequent protein kinase A (PKA) activity^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

BW245C (0.02, 0.2, and 2.0 mg/kg) in WT mice results in a significant increase in CBF, but this effect of this treatment is absent in DP1^−/− mice. BW245C attenuates functional deficits after stroke. BW245C significantly reverses these conditions that neurologic deficit is significantly augmented, whereas locomotor activity is significantly reduced after stroke in WT mice. BW245C (0.2 mg/kg) injection 1 h after stroke results in a significant decrease in brain infarction in WT mice, whereas the effect of this treatment is not observed in DP1^−/− mice. BW245C improves CBF during and after stroke. BW245C results in significantly prolonged bleeding compared with the vehicle-treated group. BW 245C (100 nM) does not significantly increase MBP-positive eosinophils in esophageal epithelium in OVA-sensitized guinea pigs.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (135.70 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7139 mL	13.5696 mL	27.1392 mL
5 mM	0.5428 mL	2.7139 mL	5.4279 mL
10 mM	0.2714 mL	1.3570 mL	2.7139 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式