Angiotensin III, human, mouse|cas:13602-53-4|西域试剂

Angiotensin III, human, mouse,99.40%

产品编号：Bellancom-P1540| CAS NO：13602-53-4| 分子式：C₄₆H₆₆N₁₂O₉| 分子量：931.09

Angiotensin III, human, mouse 是一种七肽，为血管紧张素 2 型受体 (AT2R) 激动剂，对 AT2R 和 AT1R 的 IC50 值分别为 0.648 nM 和 21.1 nM。

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货号	价格	库存与货期
Bellancom-P1540	￥350.00	杭州北京（现货）
Bellancom-P1540	￥500.00	杭州北京（现货）
Bellancom-P1540	￥700.00	杭州北京（现货）
Bellancom-P1540	￥1150.00	杭州北京（现货）
Bellancom-P1540	￥1900.00	杭州北京（现货）

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Angiotensin III, human, mouse

产品介绍

Angiotensin III, human, mouse 是一种七肽，为血管紧张素 2 型受体 (AT₂R) 激动剂，对 AT₂R 和 AT₁R 的 IC₅₀ 值分别为 0.648 nM 和 21.1 nM。

生物活性

Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT₂R) agonist, with IC₅₀s of 0.648 nM and 21.1 nM for AT₂R and AT₁R, respectively.

体外研究

Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT₂R) agonist, with IC₅₀s of 0.648 nM and 21.1 nM for AT₂R and AT₁R, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Angiotensin III (7, 14 and 28 nmol/kg/min) increases urine sodium excretion (U_NaV), fractional excretion of sodium (FE_Na), and fractional excretion of lithium (FE_Li) in SD rat. In RAS (renin-angiotensin system), Angiotensin III increases sympathetic nerve activity and vasopressin release and decreases the baroreflex leading to higher blood pressure in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (107.40 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.0740 mL	5.3700 mL	10.7401 mL
5 mM	0.2148 mL	1.0740 mL	2.1480 mL
10 mM	0.1074 mL	0.5370 mL	1.0740 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

. Bosnyak S, et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci (Lond). 2011 Oct;121(7):297-303. [Content Brief]

. Kemp BA, et al. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension. 2012 Aug;60(2):387-95. [Content Brief]

. Gao J, et al. A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors. Clin Sci (Lond). 2014 Aug;127(3):135-48. [Content Brief]

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Angiotensin III, human, mouse,99.40%

Angiotensin III, human, mouse

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