Insulin degludec|cas:844439-96-9|西域试剂

Insulin degludec,99.64%

产品编号：Bellancom-108743| CAS NO：844439-96-9

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货号	价格	库存与货期
Bellancom-108743	￥2200.00	杭州北京（现货）
Bellancom-108743	￥3500.00	杭州北京（现货）
Bellancom-108743	￥7000.00	杭州北京（现货）
Bellancom-108743	￥11000.00	杭州北京（现货）

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Insulin degludec

产品介绍

Insulin degludec 是一种超长效形式的胰岛素，用于研究 1 型和 2 型糖尿病引起的高血糖。Insulin degludec 结合胰岛素受体的 IC₅₀ 值为 19.59 nM。Insulin degludec 可用于 1 型和 2 型糖尿病的研究。

生物活性

Insulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC₅₀ value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes.

体外研究

Insulin degludec (0.001-1000 nM; 12 h) binds with insulin receptor with an IC₅₀ value of 19.59 nM.
Insulin degludec (200 nM; 10 min) increases glucose uptake in HL-1 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	HL-1 cardiomyocytes
Concentration:	200 nM
Incubation Time:	0-60 min
Result:	Decreased the level of Akt phosphorylation after 5 and 10 min treatment.

体内研究
(In Vivo)

Insulin degludec (5 U/kg; s.c. once daily for 30 days) affects glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Swiss mice with diabetes
Dosage:	5 U/kg
Administration:	Subcutaneous injection; 5 U/kg once daily for 30 days
Result:	Showed a fast response to insulin-induced hypoglycemia with a glycemic level at or slightly under 100 mg/dl after 60 min and this response effect can be abolished by cortisol. Diminished rates of glucose production and showed a low lactate production in livers. Increased the number of hepatocytes.

体内研究

Insulin degludec (5 U/kg; s.c. once daily for 30 days) affects glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Swiss mice with diabetes
Dosage:	5 U/kg
Administration:	Subcutaneous injection; 5 U/kg once daily for 30 days
Result:	Showed a fast response to insulin-induced hypoglycemia with a glycemic level at or slightly under 100 mg/dl after 60 min and this response effect can be abolished by cortisol. Diminished rates of glucose production and showed a low lactate production in livers. Increased the number of hepatocytes.

体内研究

Insulin degludec (5 U/kg; s.c. once daily for 30 days) affects glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Swiss mice with diabetes
Dosage:	5 U/kg
Administration:	Subcutaneous injection; 5 U/kg once daily for 30 days
Result:	Showed a fast response to insulin-induced hypoglycemia with a glycemic level at or slightly under 100 mg/dl after 60 min and this response effect can be abolished by cortisol. Diminished rates of glucose production and showed a low lactate production in livers. Increased the number of hepatocytes.