ADRA1D receptor antagonist 1|cas:1191908-14-1|西域试剂

ADRA1D receptor antagonist 1,98.13%

产品编号：Bellancom-135270| CAS NO：1191908-14-1| 分子式：C₁₅H₁₄Cl₂N₄O| 分子量：337.20

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-135270		￥4800.00	杭州北京（现货）
Bellancom-135270		￥8000.00	杭州北京（现货）

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ADRA1D receptor antagonist 1

产品介绍

ADRA1D receptor antagonist 1 是一个高效、选择性的，有口服活性的 α_1D 肾上腺素受拮抗剂，K_i 值为 1.6 nM。

生物活性

ADRA1D receptor antagonist 1 is a potent, selective and orally active α_1D adrenoceptor antagonist, with a K_i of 1.6 nM.

体外研究

ADRA1D receptor antagonist 1 shows low hERG inhibition.
ADRA1D receptor antagonist 1 exhibits higher selectivity for α1D-AR over α1A- and α1B-ARs .

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

ADRA1D receptor antagonist 1 (4.4 µg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rat with bladder outlet obstruction (BOO)
Dosage:	4.4 µg/kg
Administration:	Intravenous injection
Result:	Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO.

体内研究

ADRA1D receptor antagonist 1 (4.4 µg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rat with bladder outlet obstruction (BOO)
Dosage:	4.4 µg/kg
Administration:	Intravenous injection
Result:	Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (296.56 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9656 mL	14.8280 mL	29.6560 mL
5 mM	0.5931 mL	2.9656 mL	5.9312 mL
10 mM	0.2966 mL	1.4828 mL	2.9656 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献