GPRP acetate Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate|cas:157009-81-9|西域试剂

GPRP acetate Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate,99.80%

产品编号：Bellancom-P0074A| CAS NO：157009-81-9| 分子式：C₃₄H₅₆| 分子量：464.81

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货号	价格	库存与货期
Bellancom-P0074A	￥900.00	杭州北京（现货）
Bellancom-P0074A	￥1400.00	杭州北京（现货）
Bellancom-P0074A	￥2800.00	杭州北京（现货）
Bellancom-P0074A	￥4500.00	杭州北京（现货）
Bellancom-P0074A	￥7200.00	杭州北京（现货）

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GPRP acetate Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate

产品介绍

GPRP acetate (Gly-Pro-Arg-Pro acetate) 是一种纤维蛋白聚合抑制剂, 能够抑制纤维蛋白原与血小板膜糖蛋白 Ⅱb/IIIa 复合物 (糖蛋白 IIb/IIIa 受体) 之间的相互作用。

生物活性

GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa).

体外研究

GPRP acetate (0，2 和 4 mM) 增加游离凝血酶生成。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

GPRP acetate (100 mg/kg；腹腔注射，每天一次，持续 10 天) 通过改善体重减轻和死亡率显著缓解葡聚糖硫酸钠 (DSS) 诱导的结肠炎。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice with dextran sulphate sodium (DSS)-induced colitis
Dosage:	100 mg/kg
Administration:	Intraperitoneal injection; 100 mg/kg, once daily, for 10 days
Result:	Significantly inhibited body weight loss and reduced DSS-induced mortality and shortening of colon length, and decreased tissue damage and infiltration of inflammatory cells in colitis mice. Decreased levels of inflammatory cytokines in colitis mice.

体内研究

GPRP acetate (100 mg/kg；腹腔注射，每天一次，持续 10 天) 通过改善体重减轻和死亡率显著缓解葡聚糖硫酸钠 (DSS) 诱导的结肠炎。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice with dextran sulphate sodium (DSS)-induced colitis
Dosage:	100 mg/kg
Administration:	Intraperitoneal injection; 100 mg/kg, once daily, for 10 days
Result:	Significantly inhibited body weight loss and reduced DSS-induced mortality and shortening of colon length, and decreased tissue damage and infiltration of inflammatory cells in colitis mice. Decreased levels of inflammatory cytokines in colitis mice.

性状

Solid

溶解性数据

In Vitro:

H₂O : 125 mg/mL (268.93 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1514 mL	10.7571 mL	21.5142 mL
5 mM	0.4303 mL	2.1514 mL	4.3028 mL
10 mM	0.2151 mL	1.0757 mL	2.1514 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶