Danegaptide Hydrochloride GAP-134 Hydrochloride; ZP 1609 Hydrochloride|cas:943133-81-1|西域试剂

Danegaptide Hydrochloride GAP-134 Hydrochloride; ZP 1609 Hydrochloride,99.20%

产品编号：Bellancom-10913A| CAS NO：943133-81-1| 分子式：C₁₄H₁₈ClN₃O₄| 分子量：327.76

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-10913A	￥1500.00	杭州北京（现货）
Bellancom-10913A	￥2500.00	杭州北京（现货）
Bellancom-10913A	￥5000.00	杭州北京（现货）
Bellancom-10913A	￥7500.00	杭州北京（现货）
Bellancom-10913A	￥11500.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Danegaptide Hydrochloride GAP-134 Hydrochloride; ZP 1609 Hydrochloride

产品介绍

Danegaptide Hydrochloride (GAP-134 Hydrochloride) 是一种有效的，选择性的，具有口服活性的 gap-junction 修饰剂，具有抗心律不齐的作用。

生物活性

Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect.

体外研究

Danegaptide (GAP-134, compound 9f; 0.01 nM-100 μM) dose dependently reduces dye uptake in cultured C6 glioma cells in a manner.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Danegaptide (GAP-134, compound 9f) is evaluated for in vivo efficacy in the mouse CaCl₂ model after oral administration. For doses of 5-20 mg/kg po, Danegaptide significantly prolongs the time to conduction block in mice after the infusion of CaCl₂.
Danegaptide (GAP-134) is biologically active upon oral administration at an average plasma concentration of 250 nM, and reduces atrial fibrillation in a dog model. Danegaptide has no effect on heart rate, arterial blood pressure or other electrocardiogram (ECG) parameters. Danegaptide is an effective antiarrhythmic compound in the setting of ischaemia/reperfusion-induced arrhythmogenesis in barbiturate-anesthetized, open-chest beagles.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 55 mg/mL (167.81 mM)

H₂O : ≥ 50 mg/mL (152.55 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0510 mL	15.2551 mL	30.5101 mL
5 mM	0.6102 mL	3.0510 mL	6.1020 mL
10 mM	0.3051 mL	1.5255 mL	3.0510 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶