Tertiapin-Q|cas:910044-56-3|西域试剂

Tertiapin-Q,99.72%

产品编号：Bellancom-P1275| CAS NO：910044-56-3| 分子式：C₁₀₆H₁₇₅N₃₅O₂₄S₄| 分子量：2452.00

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-P1275		￥1500.00	杭州北京（现货）
Bellancom-P1275		￥3500.00	杭州北京（现货）

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Tertiapin-Q

产品介绍

Tertiapin-Q 是一种高度选择性的 GIRK1/4 异二聚体和 ROMK1 (Kir_1.1) 阻断剂。

生物活性

Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir_1.1).

体外研究

Tertiapin-Q is a highly selective blocker of G protein-coupled inwardly rectifying potassium (GIRK1/4) heterodimer and renal outer medullary potassium channel (ROMK1, Kir_1.1). Tertiapin-Q is a potent and selective blocker for Kir_1.1 renal outer medullary potassium, Kir_3.1-Kir_3.4 channels and calcium activated large conductance potassium channels (big potassium channels). The somatostatin (SS-14)-activated current is almost completely blocked (93.2±2.9%, n=5; P<0.01) by preincubation with the G protein-coupled inwardly rectifying potassium (GIRK) channel blocker Tertiapin-Q (TPN-Q).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Tertiapin-Q is a muscarinic acetylcholine receptor-operated K⁺ current (I_K,Ach) blocker. After the cessation of rapid atrial pacing, the atrial effective refractory period (AERP) is unchanged during the experimental period in the rapid atrial pacing (RAP) rabbits (n=6). Bepridil (1 mg/kg, n=5 for each group), Amiodarone (10 mg/kg, n=5 for each group), Vernakalant (3 mg/kg, n=5 for each group), Ranolazine (10 mg/kg, n=6 for each group) or Tertiapin-Q (0.03 mg/kg, n=5 for each group) on the AERP in the control and RAP rabbits. Tertiapin-Q significantly prolongs the AERP at each pacing cycle length both in the control and RAP rabbits. The extents of prolonging effect of Tertiapin-Q on the AERP in the RAP rabbits are greater than those in the control animals.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (20.39 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.4078 mL	2.0392 mL	4.0783 mL
5 mM	0.0816 mL	0.4078 mL	0.8157 mL
10 mM	0.0408 mL	0.2039 mL	0.4078 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture