Adrenomedullin (AM) (22-52), human 22-52-Adrenomedullin (human)|cas:159899-65-7|西域试剂

Adrenomedullin (AM) (22-52), human 22-52-Adrenomedullin (human),99.58%

产品编号：Bellancom-P1471| CAS NO：159899-65-7| 分子式：C₁₅₉H₂₅₂N₄₆O₄₈| 分子量：3576.04

Adrenomedullin (AM) (22-52), human 为肾上腺髓质素 (adrenomedullin receptor) 受体拮抗剂，同时在猫后肢血管床中，对降钙素基因相关肽 (CGRP) 受体也具有拮抗作用。

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货号	价格	库存与货期
Bellancom-P1471	￥1400.00	杭州北京（现货）
Bellancom-P1471	￥2400.00	杭州北京（现货）
Bellancom-P1471	￥9600.00	杭州北京（现货）

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Adrenomedullin (AM) (22-52), human 22-52-Adrenomedullin (human)

产品介绍

Adrenomedullin (AM) (22-52), human，NH₂ 末端截短的 adrenomedullin 类似物，为肾上腺髓质素 (adrenomedullin receptor) 受体拮抗剂，同时在猫后肢血管床中，对降钙素基因相关肽 (CGRP) 受体也具有拮抗作用。

生物活性

Adrenomedullin (AM) (22-52), human, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat.

体外研究

Adrenomedullin (AM) (22-52), human shows no effect on hindlimb perfusion pressure responses to adrenomedullin (ADM) at 120 nmol. However, Adrenomedullin (AM) (22-52), human selectively and reversibly decreases vasodilator responses to human calcitonin generelated peptide (hCGRP) at 30 nmol, with similar effect to that of CGRP antagonist.
Adrenomedullin (AM) (22-52), human competitively inhibits the binding of the Adrenomedullin in a dose-dependent manner, inhibits Adrenomedullin -induced cAMP accumulation in rat vascular smooth muscle cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (13.98 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2796 mL	1.3982 mL	2.7964 mL
5 mM	0.0559 mL	0.2796 mL	0.5593 mL
10 mM	0.0280 mL	0.1398 mL	0.2796 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

. Champion HC, et al. Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat. Am J Physiol. 1997 Jan;272(1 Pt 2):R234-42. [Content Brief]

. Ziolkowska A, et al. Effects of adrenomedullin and its fragment 22-52 on basal and ACTH-stimulated secretion of cultured rat adrenocortical cells. Int J Mol Med. 2003 May;11(5):613-5. [Content Brief]

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产品编号(Item Number)

批号(Lot Number)

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
WGK德国	3

Adrenomedullin (AM) (22-52), human 22-52-Adrenomedullin (human),99.58%

Adrenomedullin (AM) (22-52), human 22-52-Adrenomedullin (human)

化学品安全说明书(MSDS)

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