BAY 60-2770|cas:1027642-43-8|西域试剂

BAY 60-2770,98.97%

产品编号：Bellancom-113926| CAS NO：1027642-43-8| 分子式：C₃₅H₃₃F₄NO₅| 分子量：623.63

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-113926	￥1300.00	杭州北京（现货）
Bellancom-113926	￥2300.00	杭州北京（现货）
Bellancom-113926	￥4900.00	杭州北京（现货）
Bellancom-113926	￥8800.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

BAY 60-2770

产品介绍

BAY 60-2770 是一种有效的，选择性的，口服活性的可溶性鸟苷酸环化酶 (sGC) 活化剂。 BAY 60-2770 以一氧化氮非依赖性方式增加 sGC 的活性。BAY 60-2770 具有抗纤维化作用。

生物活性

BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect.

体外研究

体内研究

BAY 60-2770 (0.1-0.3 mg/Kg; p.o.) attenuates liver fibrosis in two rat models.
BAY 60-2770 (1 mg/kg; p.o.; daily from the 10th to the 12th week) results in amelioration of bladder dysfunction in high-fat obese mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Obese mice
Dosage:	1 mg/kg
Administration:	p.o.; daily from the 10th to the 12th week
Result:	Ameliorates detrusor dysfunction in obese mice.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Obese mice
Dosage:	1 mg/kg
Administration:	p.o.; daily from the 10th to the 12th week
Result:	Ameliorates detrusor dysfunction in obese mice.

性状

Solid

溶解性数据

In Vitro:

DMSO : 16.67 mg/mL (26.73 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6035 mL	8.0176 mL	16.0351 mL
5 mM	0.3207 mL	1.6035 mL	3.2070 mL
10 mM	0.1604 mL	0.8018 mL	1.6035 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献