BPI-9016M|cas:1528546-94-2|西域试剂

BPI-9016M,97.12%

产品编号：Bellancom-114356| CAS NO：1528546-94-2| 分子式：C₂₅H₁₈F₂N₄O₃| 分子量：460.43

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货号	价格	库存与货期
Bellancom-114356	￥4600.00	杭州北京（现货）
Bellancom-114356	￥7400.00	杭州北京（现货）
Bellancom-114356	￥15000.00	杭州北京（现货）

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BPI-9016M

产品介绍

BPI-9016M是一种有效的，口服活性的，选择性的双重 c-Met 和 AXL 酪氨酸激酶抑制剂。BPI-9016M抑制肺腺癌的肿瘤细胞生长，迁移和侵袭。

生物活性

BPI-9016M is a potent, orally active, and selective dual c-Met and AXL tyrosine kinases inhibitor. BPI-9016M suppresses tumor cell growth, migration and invasion of lung adenocarcinoma.

体外研究

BPI-9016M (6.3-25 μM; 2 weeks) inhibited cell proliferation.
BPI-9016M (12.5-50 μM; 24 hpurs) induces accumulation of more tumor cells in the G1 phase.
BPI-9016M (3.1-50 μM) reduces expression of c-Met, p-c-Met, p-AKT and p-ERK in the H1299 and A549 cells in a dose-dependent manner.
The IC₅₀ of BPI-9016M in several lung adenocarcinoma cell lines ( A549, H1299, H1650, H1975, HCC827, and PC-9 cells) as well as in primary lung adenocarcinoma cells are ranged from 5.3 μM to 27.1 μM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	A549 and H1299 cells
Concentration:	6.3, 12.5, 25 μM
Incubation Time:	2 weeks
Result:	Colony formation was significantly inhibited in a dose-dependent manner.

Cell Cycle Analysis

Cell Line:	A549 and H1299 cells
Concentration:	12.5, 25, 50 μM
Incubation Time:	24 hours
Result:	Induced accumulation of more tumor cells in the G1 phase.

体内研究
(In Vivo)

BPI-9016M (60 mg/kg; p.o.; daily for 16 or 12 days) dramatically restrains tumor growth in PDX xenografts in NOD/SCID mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NOD/SCID mice
Dosage:	60 mg/kg
Administration:	p.o.; daily for 16 or 12 days
Result:	Dramatically restrained tumor growth in PDX xenografts in NOD/SCID mice.

体内研究

BPI-9016M (60 mg/kg; p.o.; daily for 16 or 12 days) dramatically restrains tumor growth in PDX xenografts in NOD/SCID mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NOD/SCID mice
Dosage:	60 mg/kg
Administration:	p.o.; daily for 16 or 12 days
Result:	Dramatically restrained tumor growth in PDX xenografts in NOD/SCID mice.

体内研究

BPI-9016M (60 mg/kg; p.o.; daily for 16 or 12 days) dramatically restrains tumor growth in PDX xenografts in NOD/SCID mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NOD/SCID mice
Dosage:	60 mg/kg
Administration:	p.o.; daily for 16 or 12 days
Result:	Dramatically restrained tumor growth in PDX xenografts in NOD/SCID mice.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (217.19 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1719 mL	10.8594 mL	21.7188 mL
5 mM	0.4344 mL	2.1719 mL	4.3438 mL
10 mM	0.2172 mL	1.0859 mL	2.1719 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献