Zoniporide hydrochloride hydrate CP-597396 hydrochloride hydrate|cas:863406-85-3|西域试剂

Zoniporide hydrochloride hydrate CP-597396 hydrochloride hydrate,99.0%

产品编号：Bellancom-105064D| CAS NO：863406-85-3| 分子式：C₁₇H₁₉ClN₆O₂| 分子量：374.82

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-105064D	￥1600.00	杭州北京（现货）
Bellancom-105064D	￥4800.00	杭州北京（现货）
Bellancom-105064D	￥8200.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Zoniporide hydrochloride hydrate CP-597396 hydrochloride hydrate

产品介绍

Zoniporide (CP-597396) hydrochloride hydrate 是 1 型钠氢交换剂 (NHE-1) 的有效和选择性抑制剂。Zoniporide hydrochloride hydrate 抑制人 NHE-1 (IC₅₀=14 nM)，与其他 NHE 亚型相比具有大于 150 倍的选择性，并有效抑制离体 NHE-1 依赖性的人血小板溶胀 (IC₅₀=59 nM)。

生物活性

Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC₅₀=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC₅₀=59 nM).

体外研究

体内研究

Zoniporide hydrochloride hydrate (0.25-4 mg/kg; i.v.; every hour for 2 hours) elicits a dose-dependent reduction in infarct size (ED₅₀=0.45 mg/kg/h) in open chest anesthetized rabbits.
Zoniporide exhibits moderate plasma protein binding, has a t_1/2 of 1.5 hours in monkeys, and has one major active metabolite.
Zoniporide hydrochloride hydrate treatment shows the AUC_0-∞ and t_1/2 are 0.07 μg h/mL and 0.5 hours, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rabbit
Dosage:	0.25, 1, 4 mg/kg
Administration:	Every hour for 2 hours; intravenous injection
Result:	Elicited a significant dose-dependent reduction in infarct size in the anesthetized rabbit. The ED₅₀ was 0.45 mg/kg/h.

Animal Model:	Rat
Dosage:	1 mg/kg
Administration:	Intravenous injection(Pharmacokinetic Analysis)
Result:	The AUC_0-∞ and t_1/2 were 0.07 μg h/mL and 0.5 hours, respectively.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rabbit
Dosage:	0.25, 1, 4 mg/kg
Administration:	Every hour for 2 hours; intravenous injection
Result:	Elicited a significant dose-dependent reduction in infarct size in the anesthetized rabbit. The ED₅₀ was 0.45 mg/kg/h.

Animal Model:	Rat
Dosage:	1 mg/kg
Administration:	Intravenous injection(Pharmacokinetic Analysis)
Result:	The AUC_0-∞ and t_1/2 were 0.07 μg h/mL and 0.5 hours, respectively.

性状

Solid

溶解性数据

In Vitro:

H₂O : 2 mg/mL (5.34 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.6679 mL	13.3397 mL	26.6795 mL
5 mM	0.5336 mL	2.6679 mL	5.3359 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献