SERCA2a activator 1|cas:2139330-34-8|西域试剂

SERCA2a activator 1,99.54%

产品编号：Bellancom-124873| CAS NO：2139330-34-8| 分子式：C₃₂H₂₉N₃O₄S| 分子量：551.66

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-124873		￥7800.00	杭州北京（现货）
Bellancom-124873		￥12500.00	杭州北京（现货）

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SERCA2a activator 1

产品介绍

SERCA2a activator 1 (Compound A) 是一种肌/内质网 Ca²⁺ 依赖性ATPase 2a (SERCA2a) 激活剂。SERCA2a activator 1 减弱了 phospholamban 抑制作用，增强了心脏的收缩和舒张功能。SERCA2a activator 1 可用于心力衰竭的研究。

生物活性

SERCA2a activator 1 (Compound A) is a sarco/endoplasmic reticulum Ca²⁺-dependent ATPase 2a (SERCA2a) activator. SERCA2a activator 1 attenuates phospholamban inhibition and enhances the systolic and diastolic functions of the heart. SERCA2a activator 1 can be used for heart failure.

体外研究

SERCA2a activator 1 (Compound A) activates the Ca²⁺-dependent ATPase activity of cardiac sarcoplasmic reticulum (SR) vesicles but not that of skeletal muscle SR vesicles that lack phospholamban (PLN). The surface plasmon resonance assay reveals a direct interaction between SERCA2a activator 1 and PLN, suggesting that the binding of SERCA2a activator 1 to PLN attenuates its inhibition of SERCA2a, resulting in SERCA2a activation.
SERCA2a activator 1 also increases the Ca²⁺ transients and contraction and relaxation of isolated adult rat cardiomyocytes. In isolated perfused rat hearts, the SERCA2a activator 1 enhances systolic and diastolic functions.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

SERCA2a activator 1 (Compound A; 30mg/kg; intravenous injection; male Wistar rats) treatment significantly enhances the diastolic function in anesthetized normal rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (7-8 weeks old)
Dosage:	30mg/kg
Administration:	Intravenous injection
Result:	Significantly enhanced the diastolic function in anesthetized normal rats.

体内研究

SERCA2a activator 1 (Compound A; 30mg/kg; intravenous injection; male Wistar rats) treatment significantly enhances the diastolic function in anesthetized normal rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (7-8 weeks old)
Dosage:	30mg/kg
Administration:	Intravenous injection
Result:	Significantly enhanced the diastolic function in anesthetized normal rats.

性状

Solid

溶解性数据

In Vitro:

DMSO : 62.5 mg/mL (113.29 mM; ultrasonic and warming and heat to 80°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8127 mL	9.0636 mL	18.1271 mL
5 mM	0.3625 mL	1.8127 mL	3.6254 mL
10 mM	0.1813 mL	0.9064 mL	1.8127 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式