MRS2500 tetraammonium|cas:630103-23-0|西域试剂

MRS2500 tetraammonium,99.85%

产品编号：Bellancom-108658| CAS NO：630103-23-0| 分子式：C₁₃H₃₀IN₉O₈P₂| 分子量：629.28

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货号	价格	库存与货期
Bellancom-108658	￥9800.00	杭州北京（现货）
Bellancom-108658	￥18000.00	杭州北京（现货）
Bellancom-108658	￥28500.00	杭州北京（现货）

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MRS2500 tetraammonium

产品介绍

MRS2500 tetraammonium 是一种高效、选择性和稳定的 P2Y1 受体拮抗剂 (K_i=0.78 nM)。MRS2500 tetraammonium 抑制 ADP 诱导的人血小板聚集，IC₅₀ 值为 0.95 nM。具有抗血栓活性。

生物活性

MRS2500 tetraammonium is a potent, selective and stable antagonist of the P2Y1 receptor (K_i=0.78 nM for recombinant human P2Y1 receptor). MRS2500 tetraammonium inhibits the ADP-induced aggregation of human platelets with an IC₅₀ value of 0.95 nM. Antithrombotic activity.

体外研究

MRS2500 tetraammonium inhibits platelet aggregation to 10 μM ADP with an IC₅₀ of 0.95 nM in human washed platelets. MRS2500 tetraammonium inhibits platelet aggregation to 10μM ADP with an IC₅₀ of 0.49 μM in human PRP^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

MRS2500 (2 mg/kg; i.v.) decreases acute systemic thromboembolism through selective inhibition of the P2Y1 receptor.
MRS2500 exhibited strong antithrombotic efficacy in the prevention of arterial thrombosis in the monkey ECAT model^[4]..

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	20-25 g WT Male mice (acute vascular occlusion model)
Dosage:	2 mg/kg
Administration:	Intravenous
Result:	Reduced platelet consumption.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	20-25 g WT Male mice (acute vascular occlusion model)
Dosage:	2 mg/kg
Administration:	Intravenous
Result:	Reduced platelet consumption.

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (79.46 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5891 mL	7.9456 mL	15.8912 mL
5 mM	0.3178 mL	1.5891 mL	3.1782 mL
10 mM	0.1589 mL	0.7946 mL	1.5891 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献