去甲芬氟拉明盐酸盐|(+)-Norfenfluramine hydrochloride|cas:37936-89-3|西域试剂

去甲芬氟拉明盐酸盐,(+)-Norfenfluramine hydrochloride,99.02%

产品编号：Bellancom-118010A| CAS NO：37936-89-3| 分子式：C₁₀H₁₃ClF₃N| 分子量：239.67

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-118010A	￥950.00	杭州北京（现货）
Bellancom-118010A	￥1460.00	杭州北京（现货）
Bellancom-118010A	￥2810.00	杭州北京（现货）
Bellancom-118010A	￥3980.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

去甲芬氟拉明盐酸盐

产品介绍

(+)-Norfenfluramine hydrochloride 是 (+)-fenfluramine 的主要肝脏代谢物，是一种选择性的 5-HT_2B 受体激动剂 (K_i: 11.2 nM)。(+)-Norfenfluramine hydrochloride 有效地刺激磷酸肌醇的水解并增加细胞内 Ca²⁺。(+)-Norfenfluramine hydrochloride 可用于原发性肺动脉高压和心脏瓣膜病的研究。

生物活性

(+)-Norfenfluramine hydrochloride, a major hepatic metabolite of (+)-fenfluramine, is a selective 5-HT_2B receptor agonist (K_i: 11.2 nM). (+)-Norfenfluramine hydrochloride potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca²⁺. (+)-Norfenfluramine hydrochloride can be used for the research of primary pulmonary hypertension and valvular heart disease.

体外研究

(+)-Norfenfluramine (1 nM to 100 μM) hydrochloride contracts arteries with a dramatic decrease in threshold (aorta and mesenteric resistance artery) in rats.
(+)-Norfenfluramine (1 and 10 μM, 3 min) hydrochloride induces contraction in aorta from tissues of normotensive and hypertensive rats.
(+)-Norfenfluramine (0-10 μM, 3 min) hydrochloride induces 5-HT release from rat hippocampal synaptosomes by Ca²⁺-dependent way .

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

(+)-Norfenfluramine (1-300 μg/kg, i.v.) hydrochloride induces pressor response in conscious SHAM and DOCA-salt rats.
(+)-Norfenfluramine (2.5 and 5 mg/kg, i.p.) hydrochloride decreases of 5-HT and 5-HIAA levels in telencephalon and brainstem of rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Conscious SHAM and DOCA-salt rats.
Dosage:	1-300 μg/kg
Administration:	Intravenous injection (i.v.), given in a cumulative fashion at 6-min intervals.
Result:	Induced pressor response in conscious SHAM and DOCA-salt rats. (change in mean arterial blood pressure at 300 μg/kg, mm Hg, SHAM vehicle=36, SHAM ketanserin=7, DOCA=51, DOCA ketanserin=19).

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Conscious SHAM and DOCA-salt rats.
Dosage:	1-300 μg/kg
Administration:	Intravenous injection (i.v.), given in a cumulative fashion at 6-min intervals.
Result:	Induced pressor response in conscious SHAM and DOCA-salt rats. (change in mean arterial blood pressure at 300 μg/kg, mm Hg, SHAM vehicle=36, SHAM ketanserin=7, DOCA=51, DOCA ketanserin=19).

性状

Solid

溶解性数据

In Vitro:

H₂O : 18.75 mg/mL (78.23 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.1724 mL	20.8620 mL	41.7240 mL
5 mM	0.8345 mL	4.1724 mL	8.3448 mL
10 mM	0.4172 mL	2.0862 mL	4.1724 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献