H-Tyr-Tyr-OH L-Tyrosyl-L-tyrosine|cas:1050-28-8|西域试剂

H-Tyr-Tyr-OH L-Tyrosyl-L-tyrosine

产品编号：Bellancom-114782| CAS NO：1050-28-8| 分子式：C₁₈H₂₀N₂O₅| 分子量：344.36

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-114782		￥875.00	杭州北京（现货）

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H-Tyr-Tyr-OH L-Tyrosyl-L-tyrosine

产品介绍

H-Tyr-Tyr-OH (L-Tyrosyl-L-tyrosine) 是一种降压肽。H-Tyr-Tyr-OH 抑制血管紧张素转换酶 (ACE)，IC₅₀ 值为 0.028 mg/mL。H-Tyr-Tyr-OH 可用于高血压的研究。

生物活性

H-Tyr-Tyr-OH (L-Tyrosyl-L-tyrosine) is an antihypertensive peptide. H-Tyr-Tyr-OH inhibits angiotensin I-converting enzyme (ACE) with an IC₅₀ value of 0.028 mg/mL. H-Tyr-Tyr-OH can be used for the research of high blood pressure.

体外研究

H-Tyr-Tyr-OH shows inhibitory effect against ACE with an IC₅₀ value of 0.028 mg/mL.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

H-Tyr-Tyr-OH (12.5 mg/kg; intraarterial injection once) effects systolic blood pressure in vivo.
H-Tyr-Tyr-OH (0-100 mg/kg; i.p. once) effects blood pressure of spontaneously hypertensive rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Anesthetized male SpragueDawley rats
Dosage:	12.5 mg/kg
Administration:	Intraarterial injection; 12.5 mg/kg once
Result:	Significantly elevated systolic blood pressure, with a peak increase of 5 min after administration.

Animal Model:	Spontaneously hypertensive rats
Dosage:	0, 50 and 100 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Significantly reduced blood pressure of spontaneously hypertensive rats, even at a dose of 50 mg/kg.

体内研究

H-Tyr-Tyr-OH (12.5 mg/kg; intraarterial injection once) effects systolic blood pressure in vivo.
H-Tyr-Tyr-OH (0-100 mg/kg; i.p. once) effects blood pressure of spontaneously hypertensive rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Anesthetized male SpragueDawley rats
Dosage:	12.5 mg/kg
Administration:	Intraarterial injection; 12.5 mg/kg once
Result:	Significantly elevated systolic blood pressure, with a peak increase of 5 min after administration.

Animal Model:	Spontaneously hypertensive rats
Dosage:	0, 50 and 100 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Significantly reduced blood pressure of spontaneously hypertensive rats, even at a dose of 50 mg/kg.