ONO 1301 ONO-AP 500-02|cas:176391-41-6|西域试剂

ONO 1301 ONO-AP 500-02,99.06%

产品编号：Bellancom-106961| CAS NO：176391-41-6| 分子式：C₂₆H₂₄N₂O₄| 分子量：428.48

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货号	价格	库存与货期
Bellancom-106961	￥2000.00	杭州北京（现货）
Bellancom-106961	￥3500.00	杭州北京（现货）
Bellancom-106961	￥7350.00	杭州北京（现货）
Bellancom-106961	￥12500.00	杭州北京（现货）

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ONO 1301 ONO-AP 500-02

产品介绍

ONO 1301 (ONO-AP 500-02) 是一种前列腺素 (PG) I₂ 模拟物，是一种口服活性长效前列环素 (prostacyclin) 激动剂，具有血栓素合酶抑制活性。ONO 1301 促进不同细胞类型肝细胞生长因子 (HGF) 的产生，改善缺血诱导的小鼠、大鼠和猪左心室功能障碍。

生物活性

ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig.

体外研究

ONO 1301 (ONO-AP 500-02) inhibits collagen-induced aggregation in a concentration-dependent manner, with an IC₅₀ value of 460 nM.
ONO-1301 (0-1000 nM) significantly increases alkaline phosphatase (ALP) activity in the primary osteoblasts and ST2 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

ONO-1301 (6 mg/kg; p.o.; /daily for 4 weeks) improves the hemodynamic status of rats with dilated cardiomyopathy after experimental autoimmune myocarditis.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eight-week-old male Lewis rats (rat model of myosin-induced experimental autoimmune myocarditis)
Dosage:	6 mg/kg
Administration:	Orally; /daily for 4 weeks
Result:	Hemodynamic parameters and plasma brain natriuretic peptide (BNP) level were significantly improved.

体内研究

ONO-1301 (6 mg/kg; p.o.; /daily for 4 weeks) improves the hemodynamic status of rats with dilated cardiomyopathy after experimental autoimmune myocarditis.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eight-week-old male Lewis rats (rat model of myosin-induced experimental autoimmune myocarditis)
Dosage:	6 mg/kg
Administration:	Orally; /daily for 4 weeks
Result:	Hemodynamic parameters and plasma brain natriuretic peptide (BNP) level were significantly improved.

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (116.69 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3338 mL	11.6692 mL	23.3383 mL
5 mM	0.4668 mL	2.3338 mL	4.6677 mL
10 mM	0.2334 mL	1.1669 mL	2.3338 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式