H2L 5765834,LPA1,3,5拮抗剂|H2L 5765834|cas:420841-84-5|西域试剂

H2L 5765834,LPA1,3,5拮抗剂,H2L 5765834,99%

产品编号：Bellancom-15706| CAS NO：420841-84-5| 分子式：C₂₁H₁₂N₂O₇| 分子量：404.33

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货号	价格	库存与货期
Bellancom-15706	￥1300.00	杭州北京（现货）
Bellancom-15706	￥2400.00	杭州北京（现货）
Bellancom-15706	￥4300.00	杭州北京（现货）
Bellancom-15706	￥7300.00	杭州北京（现货）
Bellancom-15706	￥13500.00	杭州北京（现货）

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H2L 5765834,LPA1,3,5拮抗剂

产品介绍

H2L 5765834 是溶血磷脂酸受体 LPA₁，LPA₃ 和 LPA₅ 的拮抗剂，IC₅₀ 值分别为 94，752 和 463 nM。

生物活性

H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA₁, LPA₃, and LPA₅, with IC₅₀s of 94, 752, and 463 nM respectively.

体外研究

H2L 5765834 displays no effect on LPA₂ or LPA₄ receptors.
H2L 5765834 inhibits LPA-induced platelet shape change with an IC₅₀ of 13.73±2.52 μM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

H2L 5765834 (20 mg/kg; i.p.) could not affect the LPA-induced decrease of alanine transaminase (ALT) in the acetaminophen (APAP) overdose-induced acute liver injury model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

H2L 5765834 (20 mg/kg; i.p.) could not affect the LPA-induced decrease of alanine transaminase (ALT) in the acetaminophen (APAP) overdose-induced acute liver injury model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (618.31 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4732 mL	12.3661 mL	24.7323 mL
5 mM	0.4946 mL	2.4732 mL	4.9465 mL
10 mM	0.2473 mL	1.2366 mL	2.4732 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式