F 16915|cas:92510-91-3|西域试剂

F 16915,99.39%

产品编号：Bellancom-19886| CAS NO：92510-91-3| 分子式：C₂₈H₃₇NO₂| 分子量：419.60

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货号	价格	库存与货期
Bellancom-19886	￥12520.00	杭州北京（现货）
Bellancom-19886	￥20030.00	杭州北京（现货）
Bellancom-19886	￥32730.00	杭州北京（现货）

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F 16915

产品介绍

F 16915 是二十二碳六烯酸 (DHA，HY-B2167) 的衍生物，也是一种有效的 DHA 前体。F 16915 可预防心力衰竭引起的心房颤动。

生物活性

F 16915, a Docosahexaenoic Acid (DHA, HY-B2167) derivative, is a potent pro-agent of DHA. F 16915 can prevent heart failure-induced atrial fibrillation.

体外研究

体内研究

F 16915 (100 mg/kg; daily oral gavage for 2 months) reduces marked dilation of the left atrial (LA) cavity and the steep decline of left ventricular (LV) contractile function occurring 2 months after infarction and reperfusion in rats.
F 16915 (1-5 g/day for 4 weeks) significantly reduces the infarct size and prevents the left ventricular free wall thinning.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (220-300 g) with heart failure induced by occlusion of left descending coronary artery and 2 months reperfusion
Dosage:	100 mg/kg
Administration:	Daily oral gavage
Result:	Reduced the infarct size. Prevented the left ventricular free wall thinning. Reduced the de-phosphorylation of connexin43 from atria tissue.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (220-300 g) with heart failure induced by occlusion of left descending coronary artery and 2 months reperfusion
Dosage:	100 mg/kg
Administration:	Daily oral gavage
Result:	Reduced the infarct size. Prevented the left ventricular free wall thinning. Reduced the de-phosphorylation of connexin43 from atria tissue.

性状

Oil

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (238.32 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3832 mL	11.9161 mL	23.8322 mL
5 mM	0.4766 mL	2.3832 mL	4.7664 mL
10 mM	0.2383 mL	1.1916 mL	2.3832 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献