TAS-301|cas:193620-69-8|西域试剂

TAS-301,99.50%

产品编号：Bellancom-18965| CAS NO：193620-69-8| 分子式：C₂₃H₁₉NO₃| 分子量：357.40

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货号	价格	库存与货期
Bellancom-18965	￥500.00	杭州北京（现货）
Bellancom-18965	￥800.00	杭州北京（现货）
Bellancom-18965	￥1400.00	杭州北京（现货）
Bellancom-18965	￥2400.00	杭州北京（现货）
Bellancom-18965	￥3400.00	杭州北京（现货）

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TAS-301

产品介绍

TAS-301 是一种平滑肌迁移和增殖抑制剂，能够抑制 PDGF 诱导的 PKC 的活化。

生物活性

TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, and inhibits PKC activation induced by PDGF.

体外研究

TAS-301 (1-10 μM) concentration-dependently inhibits PKC activation and Ca²⁺ influx, induced by PDGF, with 62.7% inhibition on PKC activation at 10 μM, and reduces PMA-induced AP-1, with 38% and 67.6% inhibition at 3 and 10 μM, respectively. TAS-301 (0.3-3 μM) dose-dependently reduces the migration of cells induced by growth factors (PDGF-BB, IGF-1,HB-EGF). TAS-301 (1-10 μM) also decreases bFGF-induced BrdU incorporation, especially at 3 and 10 μM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

TAS-301 (3-100 mg/kg, p.o.) dose-dependently reduces the neointimal thickening and I/M ratio and decreases the level of intimal cells in rats 14 days after balloon injury.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

TAS-301 (3-100 mg/kg, p.o.) dose-dependently reduces the neointimal thickening and I/M ratio and decreases the level of intimal cells in rats 14 days after balloon injury.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 38 mg/mL (106.32 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7980 mL	13.9899 mL	27.9799 mL
5 mM	0.5596 mL	2.7980 mL	5.5960 mL
10 mM	0.2798 mL	1.3990 mL	2.7980 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式