Tebentafusp (IMCgp100) is a bispecific fusion protein to target gp100 peptide-HLA-A*02:01 (a melanoma-associated antigen). Tebentafusp guides T cells to kill gp100-expressing tumor cells via a high affinity T-cell receptor (TCR) binding domain and an anti-CD3 T-cell engaging domain. Tebentafusp leads to inflammatory cytokines and cytolytic proteins production, resulting in the direct lysis of tumour cells.

Tebentafusp 是一种识别由 HLA-A*0201 表达的黑色素瘤特异性蛋白 gp100 衍生的肽的ImmTAC。
Tebentafusp (31 pM, 82 pM 和131 pM; 16 h) 刺激 PBMC 对 Mel526 细胞而不是 gp100 阴性 A375 细胞的细胞毒性脱颗粒活性。
Tebentafusp (100 pM; 0-50h) 介导 CD8⁺ T 细胞 (虽然存在调节性 T 细胞) 的杀伤，表现在40-48小时内 caspase 3/7 的激活。
Tebentafusp (100 pM; 0-80 h) 触发 CD4⁺ T 细胞亚群对黑素瘤细胞的细胞溶解。
Tebentafusp (1, 12, 31, 82 和131 pM; 24 h 或 96 h) 增加颗粒酶 B 的含量，并诱导 CD4⁺ 和 CD8⁺ 细胞广泛释放细胞因子和趋化因子。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Tebentafusp (10 μg/kg; 静脉注射) 在小鼠黑色素瘤模型中抑制肿瘤的生长^[4]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Tebentafusp (10 μg/kg; 静脉注射) 在小鼠黑色素瘤模型中抑制肿瘤的生长^[4]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Middleton MR, et al. Tebentafusp, A TCR/Anti-CD3 Bispecific Fusion Protein Targeting gp100, Potently Activated Antitumor Immune Responses in Patients with Metastatic Melanoma. Clin Cancer Res. 2020 Nov 15;26(22):5869-5878.  [Content Brief]

  . Dhillon S. Tebentafusp: First Approval. Drugs. 2022 Apr;82(6):703-710.  [Content Brief]

  . Boudousquie C, et al. Polyfunctional response by ImmTAC (IMCgp100) redirected CD8+ and CD4+ T cells. Immunology. 2017 Nov;152(3):425-438.  [Content Brief]

  [4]. Baeuerle P A, et al. Passive immunotherapy by T cell–engaging bispecifi c antibodies[M]//Cancer Vaccines. CRC Press, 2015: 266-278.