TRV056,99.62%
产品编号：Bellancom-P3137| CAS NO：812644-79-4| 分子式：C52H74N14O13| 分子量：1103.23
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TRV056
| 产品介绍 | TRV056 是 1 型血管紧张素 II 受体 (AT1R) 的 Gq-偏置的配体。TRV056 有效刺激细胞 Gq 介导的信号传导。TRV056 可用于开发 Gq-偏置的 AT1R 激动剂。 | ||||||
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| 生物活性 | TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists. | ||||||
| 体外研究 |
TRV056 is a “gain-of-function” ligand that have >10-fold greater allosteric coupling to Gq than AngII and is also more efficacious in stimulating cellular Gq-mediated signaling (e.g., IP1 generation). Compared to the endogenous ligand angiotensin II (AngII), “Gq-biased” AT1R agonists are more efficacious in stimulating Gq-mediated cellular signaling and in allosterically promoting Gq coupling. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||
| 体内研究 | |||||||
| 体内研究 | |||||||
| 性状 | Solid | ||||||
| 溶解性数据 | |||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||
| 储存方式 |
Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) | ||||||
| 参考文献 |
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