JNc-440|cas:1119503-63-7|西域试剂

JNc-440,98.04%

产品编号：Bellancom-120514| CAS NO：1119503-63-7| 分子式：C₂₆H₂₄N₄O₃| 分子量：440.49

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-120514		￥1000.00	杭州北京（现货）

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JNc-440

产品介绍

JNc-440 是一种有效的抗高血压剂。JNc-440 可增强内皮细胞瞬时受体电位香草酸亚型 4 (TRPV4) 和钙离子激活钾通道 3 (KCa2.3) 的相互作用。JNc-440 还能增强小鼠血管扩张，具有降压作用。

生物活性

JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of TRPV4 and Ca²⁺-activated potassium channel 3 (KCa2.3) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice.

体外研究

体内研究

JNc-440 (1 mg/kg; IV; single dosage) improves endothelium-dependent relaxation in small resistance arteries and to lower blood pressure.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	TRPV4^-/- and wild‐type C57BL/6J mice (hypertensive induced by NOS inhibitor Nω-nitro-L-arginine, AngII and high-salt diet)
Dosage:	1 mg/kg
Administration:	IV; single dosage
Result:	Increased the impaired TRPV4‐KCa2.3 interaction to improve endothelium‐dependent relaxation in small resistance arteries and to lower blood pressure.

体内研究

JNc-440 (1 mg/kg; IV; single dosage) improves endothelium-dependent relaxation in small resistance arteries and to lower blood pressure.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	TRPV4^-/- and wild‐type C57BL/6J mice (hypertensive induced by NOS inhibitor Nω-nitro-L-arginine, AngII and high-salt diet)
Dosage:	1 mg/kg
Administration:	IV; single dosage
Result:	Increased the impaired TRPV4‐KCa2.3 interaction to improve endothelium‐dependent relaxation in small resistance arteries and to lower blood pressure.