A 71915,99.29%
产品编号：Bellancom-P2026| CAS NO：132956-87-7| 分子式：C69H116N26O15S2| 分子量：1613.95
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A 71915
| 产品介绍 | A 71915 是一种具有高效、竞争性的 natriuretic peptide receptor A (ANP, NPRA) 拮抗剂 (pKi= 9.18). A71915 的剂量依赖性取代 [125I]ANP，Ki为0.65 nM。A71915 (pA2= 9.48) 对大鼠 ANP 诱导的 NB-OK-1 细胞产生 cGMP 的作用。 | ||||||||
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| 生物活性 | A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells. | ||||||||
| 体外研究 |
A 71915 combines to Neuroblastoma NB-OK-1 cells, is used in the Cyclic GMP assay. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||
| 体内研究 |
A 71915 (5 μl; i.m.; 25-30 g male CD-1 mice) affects BNP (1 nmol)- and GRP (0.1 nmol)-induced scratching. A 71915 (30 μg/ kg/ day) inhibits NS-398 on blood pressure decreased. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究 |
A 71915 (5 μl; i.m.; 25-30 g male CD-1 mice) affects BNP (1 nmol)- and GRP (0.1 nmol)-induced scratching. A 71915 (30 μg/ kg/ day) inhibits NS-398 on blood pressure decreased. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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| 性状 | Solid | ||||||||
| 溶解性数据 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
| 储存方式 |
Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) | ||||||||
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