(Rac)-Etavopivat (Rac-FT-4202),99.87%
产品编号：Bellancom-139573A| CAS NO：2622070-93-1| 分子式：C22H23N3O6S| 分子量：457.50
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(Rac)-Etavopivat (Rac-FT-4202)
| 产品介绍 | (Rac)-Etavopivat((Rac)-FT-4202) 是Etavopivat (HY-139573)异构体。Etavopivat 是一种具有口服活性的的红细胞丙酮酸激酶-R (PKR) 激活剂，可以用于镰状细胞病和其他血红蛋白疾病研究。 | ||||||||||||
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| 生物活性 | (Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat (HY-139573). Etavopivat is an orally active erythrocyte pyruvate kinase-R (PKR) activator that can be used in studies of sickle cell disease and other haemoglobinopathies. | ||||||||||||
| 体外研究 |
Etavopivat (20 μM, 4 h)可以改善人红细胞中血红蛋白-氧亲和力并降低了镰状点 (PoS)。 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||
| 体内研究 |
Etavopivat（口服，3-22mg/kg，每天一次，5天）在 8 mg/kg和 22 mg/kg 的剂量下引起食蟹猴 2,3-DPG 和 ATP 的增加。 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||
| 体内研究 |
Etavopivat（口服，3-22mg/kg，每天一次，5天）在 8 mg/kg和 22 mg/kg 的剂量下引起食蟹猴 2,3-DPG 和 ATP 的增加。 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||
| 性状 | Solid | ||||||||||||
| 溶解性数据 | |||||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| 储存方式 |
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| 参考文献 |
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