Talinolol Cordanum|cas:57460-41-0|西域试剂

Talinolol Cordanum,99.64%

产品编号：Bellancom-108286| CAS NO：57460-41-0| 分子式：C₂₀H₃₃N₃O₃| 分子量：363.49

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货号	价格	库存与货期
Bellancom-108286	￥1500.00	杭州北京（现货）
Bellancom-108286	￥2700.00	杭州北京（现货）
Bellancom-108286	￥9000.00	杭州北京（现货）

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Talinolol Cordanum

产品介绍

Talinolol (Cordanum) 是一种长效、心脏选择性的 β1-肾上腺素能受体阻滞剂。Talinolol 具有心脏保护和抗高血压活性。Talinolol 也是众所周知且经常使用的 P-糖蛋白 (P-gp) 活性探针底物。

生物活性

Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity.

体外研究

Human OATP1A2-, rat Oatp1a5-, and rat Mdr1a-mediated Talinolol transport can be inhibited by naringin, with IC₅₀s of 343, 12.7, and 604 μM, respectively, in LLC-PK1 cell and Xenopus laevis oocyte systems.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Talinolol (20 mg/kg; i.p.) plasma and liver AUC_{0-5 h are increased by Zosuquidar administration.

Bioavailability of Talinolol can be enhanced by coadministration with grapefruit juice (GFJ) in rats.}

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (275.11 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7511 mL	13.7555 mL	27.5111 mL
5 mM	0.5502 mL	2.7511 mL	5.5022 mL
10 mM	0.2751 mL	1.3756 mL	2.7511 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献