Rodatristat KAR5417|cas:1673568-73-4|西域试剂

Rodatristat KAR5417

产品编号：Bellancom-120083| CAS NO：1673568-73-4| 分子式：C₂₇H₂₇ClF₃N₅O₃| 分子量：561.98

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-120083		￥10200.00	杭州北京（现货）
Bellancom-120083		￥16500.00	杭州北京（现货）

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Rodatristat KAR5417

产品介绍

Rodatristat (KAR5417) 是一种有效的 tryptophan hydroxylase 1 (TPH1) 和 TPH2 抑制剂，其 IC₅₀ 值分别为 33 nM 和 7 nM，并显著降低小鼠肠道中的血清素 (5-HT) 水平。

生物活性

Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC₅₀s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice.

体外研究

体内研究

Rodatristat (10-50 mg/kg; oral administration; mice) treatment decreases intestinal 5-HT concentrations at 50 mg/kg, their efficacy drop off significantly at the lower 10 mg/kg dose.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice
Dosage:	10 mg/kg and 50 mg/kg
Administration:	Oral administration
Result:	Decreased intestinal 5-HT concentrations at 50 mg/kg, their efficacy dropped off significantly at the lower 10 mg/kg dose.

体内研究

Rodatristat (10-50 mg/kg; oral administration; mice) treatment decreases intestinal 5-HT concentrations at 50 mg/kg, their efficacy drop off significantly at the lower 10 mg/kg dose.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice
Dosage:	10 mg/kg and 50 mg/kg
Administration:	Oral administration
Result:	Decreased intestinal 5-HT concentrations at 50 mg/kg, their efficacy dropped off significantly at the lower 10 mg/kg dose.