Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC₅₀ of 132 nM.

在 2mM Ca²⁺ 存在的情况下，Calindol 刺激磷脂酰肌醇 (PI) 在表达大鼠或人 CaSR 的细胞中的 EC₅₀ 分别为 1.0 μM 或 0.31 μM。
在线肌造影研究中，Calindol (1-10 µM) 抑制 Methoxamine 和 KCl 诱导的预收缩张力，并抑制兔肠系膜动脉中的全细胞电压门控 Ca²⁺ 通道 (VGCC) 电流。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

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