DC-U4106|cas:2410534-62-0|西域试剂

DC-U4106,99.03%

产品编号：Bellancom-150505| CAS NO：2410534-62-0| 分子式：C₂₉H₂₇N₅O₅| 分子量：525.56

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-150505		￥7800.00	杭州北京（现货）
Bellancom-150505		￥12500.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

DC-U4106

产品介绍

DC-U4106 是一种 USP8 靶向抑制剂，其 K_d 值为 4.7 μM，IC₅₀ 值为 1.2 μM。DC-U4106 可作用于泛素化途径，促进 Erα 的降解。DC-U4106 可以抑制剂肿瘤细胞的生长，具有较小毒性，可用于乳腺癌研究。

生物活性

DC-U4106 is a USP8 targeting inhibitor with the K_dvalue of 4.7 μM and the IC₅₀ value of 1.2 μM. DC-U4106 can target the ubiquitin pathway and facilitate the degradation of Erα. DC-U4106 inhibits tumor growth with minimal toxicity and has the potential for the research of breast cancer.

体外研究

DC-U4106 (1.2-45.2 μM) inhibits USP8 and USP2 with the IC₅₀ values of 1.2 μM and 58.4 μM, respectively, and no activity in USP7.
DC-U4106 (0-7 μM, 24 hours) reduces mRNA levels of ERα and PR.
DC-U4106 (0-5 μM, 24 hours) can regulate the RTK pathway related proteins and the expression of ERα and PR proteins.
DC-U4106 (0-5 μM, 12 hours) can induce apoptosis and inhibit cell proliferation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	USP8-positive cell line MCF-7
Concentration:	0-5 μM
Incubation Time:	24 hours
Result:	Reduced the expression of EGFR, ErbB2, and ErbB3 proteins with increasing concentrations and caused degradation of ERα and PR proteins.

RT-PCR

Cell Line:	USP8-positive cell line MCF-7
Concentration:	0-7 μM
Incubation Time:	24 hours
Result:	Reduced mRNA levels of ERα and PR.

Cell Proliferation Assay

Cell Line:	USP8-positive cell line MCF-7
Concentration:	0-5 μM
Incubation Time:
Result:	Inhibited cell growth in a dose-dependent manner.

Apoptosis Analysis

Cell Line:	USP8-positive cell line MCF-7
Concentration:	0-5 μM
Incubation Time:	12 hours
Result:	Resulted in increasing in the proportion of apoptotic cells with increasing concentrations.

体内研究
(In Vivo)

DC-U4106 (intraperitoneal injection, 5 mg/kg or 20 mg/kg, every 2 days, 14 days) inhibits the proliferation of tumors and no significantly effects on body weight, organ morphology and structure in BALB/c nude mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c nude mice
Dosage:	5 mg/kg , 20 mg/kg
Administration:	Intraperitoneal injection, Every 2 days, 14 days
Result:	Inhibited tumor growth significantly at a concentration of 20 mg/kg.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c nude mice
Dosage:	5 mg/kg , 20 mg/kg
Administration:	Intraperitoneal injection, Every 2 days, 14 days
Result:	Inhibited tumor growth significantly at a concentration of 20 mg/kg.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c nude mice
Dosage:	5 mg/kg , 20 mg/kg
Administration:	Intraperitoneal injection, Every 2 days, 14 days
Result:	Inhibited tumor growth significantly at a concentration of 20 mg/kg.

性状

Solid

溶解性数据

In Vitro:

THF : 10 mg/mL (19.03 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9027 mL	9.5137 mL	19.0273 mL
5 mM	0.3805 mL	1.9027 mL	3.8055 mL
10 mM	0.1903 mL	0.9514 mL	1.9027 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献