MM 54,99.21%
产品编号：Bellancom-P2271| CAS NO：1313027-43-8| 分子式：C70H121N29O15S4| 分子量：1737.17
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MM 54
| 产品介绍 | MM 54 (compound 5) 是竞争性的 APJ 拮抗剂，其 IC50 值为 93 nM。MM 54作为一种有效的和选择性的 apelin 结合和 APLNR 激活的抑制剂。 | ||||||||
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| 生物活性 | MM 54 (compound 5) is a competitive antagonist at APJ, with an IC50 of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation. | ||||||||
| 体外研究 |
MM 54 inhibits more than 95% of apelin binding to APLNR at the dose of 10 µM. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||
| 体内研究 |
MM 54 (2 mg/kg, ip, bi-weekly for 4 weeks) possesses anti-tumor activity in glioblastoma models with no obvious toxicity. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究 |
MM 54 (2 mg/kg, ip, bi-weekly for 4 weeks) possesses anti-tumor activity in glioblastoma models with no obvious toxicity. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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| 性状 | Solid | ||||||||
| 溶解性数据 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
| 储存方式 |
Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) | ||||||||
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