IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6⁺ ovarian and testicular cancer cell lines.

IMAB027 特异性地与 CLDN6 结合，而不是与其他密切相关的家族成员，如 Claudins 3，4 和 9 结合。
IMAB027 在表达 CLDN6⁺ 的卵巢癌和睾丸癌细胞系中诱导靶细胞产生选择性抗体依赖细胞介导的细胞毒性 (ADCC) 和补体依赖细胞毒性 (CDC)。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

IMAB027 可降低人 CLDN6⁺ 细胞移植的小鼠肿瘤的肿瘤生长并提高总生存率。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

IMAB027 可降低人 CLDN6⁺ 细胞移植的小鼠肿瘤的肿瘤生长并提高总生存率。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Türeci Ö, t al. The anti-claudin 6 antibody, IMAB027, induces antibody-dependent cellular and complement-dependent cytotoxicity in claudin 6-expressing cancer cells[J]. Cancer Research, 2018, 78(13_Supplement): 882-882.