Kongensin A|cas:885315-96-8|西域试剂

Kongensin A,98.0%

产品编号：Bellancom-N3417| CAS NO：885315-96-8| 分子式：C₂₂H₃₀O₅| 分子量：374.47

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-N3417		￥9500.00	杭州北京（现货）
Bellancom-N3417		￥20800.00	杭州北京（现货）

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Kongensin A

产品介绍

Kongensin A 是一种从 Croton kongensis 中分离的天然产物。 Kongensin A 是一种有效的，共价的 HSP90 抑制剂，可阻断 RIP3 依赖性坏死病。Kongensin A 是一种有效的坏死性抑制剂和凋亡诱导剂，并具有潜在的抗坏死性和消炎性应用。

生物活性

Kongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent HSP90 inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications.

体外研究

Kongensin A (0-15 μM; 6 hours; HT29 cells) treatment induces caspase activation and apoptosis in multiple cancer cell lines in a dosage-dependent manner.
Kongensin A (0-15 μM; 24 hours; HT29 cells) treatment induces the degradation of RIPK1 and oncogenic kinases such as ERBB2, AKT, EGFR, and B-raf, and induces the up-regulation of HSP90A and HSP90B.
Kongensin A covalently binds to cysteine 420 in the middle domain of HSP90 and dissociates HSP90 from its cochaperone CDC37. The HSP90-CDC37 complex is required for RIP3 activation, KA blocks LPS/Smac mimetics/Z-VAD and RIP3 polymerization-induced cell death, in which cell death is dependent on RIP3 but not its upstream kinase RIP1.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis

Cell Line:	HT29 cells
Concentration:	0 μM, 2.5 μM, 5 μM, 15 μM
Incubation Time:	6 hours
Result:	Induced caspase activation and apoptosis in a dosage-dependent manner.

Western Blot Analysis

Cell Line:	HT29 cells
Concentration:	0 μM, 2.5 μM, 5 μM, 15 μM
Incubation Time:	24 hours
Result:	Induced the degradation of RIPK1 and oncogenic kinases such as ERBB2, AKT, EGFR, and B-raf, and induced the up-regulation of HSP90A and HSP90B.