PD 168368|cas:204066-82-0|西域试剂

PD 168368,98.78%

产品编号：Bellancom-116216| CAS NO：204066-82-0| 分子式：C₃₁H₃₄N₆O₄| 分子量：554.64

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-116216	￥1000.00	杭州北京（现货）
Bellancom-116216	￥3000.00	杭州北京（现货）
Bellancom-116216	￥4800.00	杭州北京（现货）
Bellancom-116216	￥9600.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

PD 168368

产品介绍

PD 168368 是一种有效的、竞争性的选择性神经调节蛋白 B 受体 (NMB-R) 拮抗剂，K_i 为 15-45 nM。 PD 168368 是神经调节素 B 受体（NMBR; IC₅₀=96 nM）和胃泌素释放肽受体 (GRPR; IC₅₀=3500 nM)）的双重拮抗剂。PD 168368 还是一种 FPR1/FPR2/FPR3 的混合激动剂，EC₅₀ 分别为 0.57、0.24 和 2.7 nM。

生物活性

PD 168368 is a potent, competitive, and selective neuromedin B receptor (NMB-R) antagonist with the K_i of 15–45 nM. PD 168368 is neuromedin B receptor (NMBR; IC₅₀=96 nM) / gastrin-releasing peptide receptor (GRPR IC₅₀=3500 nM) antagonist. PD 168368 also is a mixed FPR1/FPR2/FPR3 agonist with EC₅₀s of 0.57, 0.24, and 2.7 nM, respectively.

体外研究

PD 168368 (PD168368) is highly active and stimulated [Ca²⁺]_I release in human neutrophils with EC₅₀ values in the nanomolar range.
PD 168368 (PD168368) suppresses migration and invasion of the human breast cancer cell line MDA-MB-231. PD 168368 reduces epithelial-mesenchymal transition (EMT) of breast cancer cells by E-cadherin upregulation and vimentin downregulation. PD 168368 (5 μM) inhibits migration and invasiveness in breast cancer cells^[4].
PD 168368 (10 μM) suppresses the activation of mTOR/p70S6K/4EBP1 and AKT/GSK-3β pathways in breast cancer cells^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:	Human breast cancer cell line MDA-MB-231
Concentration:	5 μM
Incubation Time:	24 hours
Result:	Clearly decreased the migratory ability of MDA-MB-231 cells in a Boyden chamber migration assay.

Cell Viability Assay^[4]

Cell Line:	MDA-MB-231 cells
Concentration:	10 μM
Incubation Time:	0, 0.5, 1, 2, 4, 8, and 16 hours
Result:	Decreased phosphorylation levels of mTOR, p70S6K, 4EBP1, AKT and GSK-3β in a time-dependent manner.

体内研究
(In Vivo)

PD 168368 (PD168368) potently inhibits in vivo metastasis of breast cancer. PD 168368 (1.2 mg/kg; intraperitoneal injection for 30 days) inhibits metastasis of breast cancer in mice^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c-nude mice (age 8-10 weeks) bearing MDA-MB-231 xenograft model^[4]
Dosage:	1.2 mg/kg
Administration:	Intraperitoneal injection for 30 days
Result:	No metastatic tumor nodules were observed in lungs of PD 168368-treated mice compared to PEG-injected mice.

体内研究

PD 168368 (PD168368) potently inhibits in vivo metastasis of breast cancer. PD 168368 (1.2 mg/kg; intraperitoneal injection for 30 days) inhibits metastasis of breast cancer in mice^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c-nude mice (age 8-10 weeks) bearing MDA-MB-231 xenograft model^[4]
Dosage:	1.2 mg/kg
Administration:	Intraperitoneal injection for 30 days
Result:	No metastatic tumor nodules were observed in lungs of PD 168368-treated mice compared to PEG-injected mice.

体内研究

PD 168368 (PD168368) potently inhibits in vivo metastasis of breast cancer. PD 168368 (1.2 mg/kg; intraperitoneal injection for 30 days) inhibits metastasis of breast cancer in mice^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c-nude mice (age 8-10 weeks) bearing MDA-MB-231 xenograft model^[4]
Dosage:	1.2 mg/kg
Administration:	Intraperitoneal injection for 30 days
Result:	No metastatic tumor nodules were observed in lungs of PD 168368-treated mice compared to PEG-injected mice.

性状

Solid

溶解性数据

In Vitro:

DMSO : 30 mg/mL (54.09 mM; Need ultrasonic and warming)

DMF : 10 mg/mL (18.03 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8030 mL	9.0149 mL	18.0297 mL
5 mM	0.3606 mL	1.8030 mL	3.6059 mL
10 mM	0.1803 mL	0.9015 mL	1.8030 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式