(S-特拉唑嗪)|(S)-Terazosin|cas:109351-33-9|西域试剂

(S-特拉唑嗪),(S)-Terazosin,99.90%

产品编号：Bellancom-B0371D| CAS NO：109351-33-9| 分子式：C₁₉H₂₅N₅O₄| 分子量：387.43

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货号	价格	库存与货期
Bellancom-B0371D	￥2500.00	杭州北京（现货）
Bellancom-B0371D	￥3500.00	杭州北京（现货）
Bellancom-B0371D	￥9500.00	杭州北京（现货）
Bellancom-B0371D	￥15000.00	杭州北京（现货）

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(S-特拉唑嗪)

产品介绍

(S)-Terazosin 是 Terazosin 的有活性的 S 型异构体，也是一种有效的，高亲和力的 α-肾上腺素受体拮抗剂，对 α1a，α1b 和 α1d-肾上腺素受体的 K_i 值分别为 3.91 nM，0.79 nM 和 1.16 nM。(S)-Terazosin 对 α2a，α2B 和 α2c-肾上腺素受体也具有高亲和力，K_i 值分别为 729 nM，3.5 nM 和 46.4 nM。

生物活性

(S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinity α-adrenoceptor antagonist with K_i values of 3.91 nM, 0.79 nM and 1.16 nM for α1a, α1b and α1d-adrenoceptor, respectively. (S)-Terazosin also has high-affinity for α2a, α2B and α2c-adrenoceptor with K_i values of 729 nM, 3.5 nM and 46.4 nM, respectively.

体外研究

The racemic compound and its enantiomers show high and apparently equal affinity for subtypes of α1-adrenoceptors with K_i values in the low nanomolar range, and showed potent antagonism of α1-adrenoceptors in isolated tissues, with the enantiomers approximately equipotent to the racemate at each α1-adrenoceptor subtype. At α2b sites, (R)-Terazosin binds less potently than either the (S)-Terazosin or racemate.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

(S)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC30 of 6.93. (s)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA2 values of 8.3 and 6.12, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 150 mg/mL (387.17 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5811 mL	12.9056 mL	25.8111 mL
5 mM	0.5162 mL	2.5811 mL	5.1622 mL
10 mM	0.2581 mL	1.2906 mL	2.5811 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式