SOP1812 QN-302|cas:2546091-70-5|西域试剂

SOP1812 QN-302,98.37%

产品编号：Bellancom-148012| CAS NO：2546091-70-5| 分子式：C₄₅H₅₇N₇O₆| 分子量：791.98

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-148012		￥5000.00	杭州北京（现货）
Bellancom-148012		￥8500.00	杭州北京（现货）

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SOP1812 QN-302

产品介绍

SOP1812 (QN-302) 是一种 naphthalene diimide (ND) 衍生物，具有抗肿瘤活性。SOP1812 能够与quadruplex arrangements (G4s) 结合，并下调多个癌症基因通路。SOP1812 对 hTERT G4 和 HuTel21 具有很强的亲和力，其 K_D 值分别为 4.9 和 28.4 nM。G4SOP1812 可用于癌症的研究。

生物活性

SOP1812 (QN-302) is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with K_D values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer.

体外研究

SOP1812 (0-50 nM; 96 h) inhibits the proliferation of many cancer cells.
SOP1812 (0-800 nM; 6-24 h) shows great affinity to hTERT G4 and HuTel21 G4.
SOP1812 (40 nM; 6-24 h) affects Wnt/β-catenin, axon guidance, Hippo, MAPK and Rap1 pathways.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cell lines
Concentration:	0-50 nM
Incubation Time:	96 hours
Result:	Showed anti-proliferation ability to MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cells with GI₅₀ values of 1.3, 1.4, 5.9 and 2.6 nM, respectively.

Cell Viability Assay

Cell Line:	PANC-1 cells
Concentration:	0, 100, 400 and 800 nM
Incubation Time:	6 and 24 hours
Result:	Binded to hTERT G4 and HuTel21 G4 with K_D values of 4.9 and 28.4 nM, respectively.

Cell Viability Assay

Cell Line:	MIA PaCa-2 Cells
Concentration:	40 nM
Incubation Time:	6 and 24 hours
Result:	Affected WNT5B, DVL1, AXIN and APC2 expression which includes in Wnt/β-catenin pathway and also showed effects on axon guidance, Hippo, MAPK, and Rap1 pathways.

体内研究
(In Vivo)

SOP1812 (1 mg/kg; i.v. once or twice per week for 28 days) shows anti-tumor activity in MIA PaCa-2 xenografts mice and KPC mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic nude mice with MIA PaCa-2 xenografts
Dosage:	1 mg/kg
Administration:	Intravenous injection; 1 mg/kg once or twice per week; for 28 days
Result:	Showed complete tumor regression and no significant tumor regrowth after day 28 on several animals.

Animal Model:	KPC mice with PDAC symptoms
Dosage:	1 mg/kg
Administration:	Intravenous injection; 1 mg/kg once per week; for 3 weeks
Result:	Significantly extended survival of KPC mice and showed a better effect than gemcitabine.

体内研究

SOP1812 (1 mg/kg; i.v. once or twice per week for 28 days) shows anti-tumor activity in MIA PaCa-2 xenografts mice and KPC mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic nude mice with MIA PaCa-2 xenografts
Dosage:	1 mg/kg
Administration:	Intravenous injection; 1 mg/kg once or twice per week; for 28 days
Result:	Showed complete tumor regression and no significant tumor regrowth after day 28 on several animals.

Animal Model:	KPC mice with PDAC symptoms
Dosage:	1 mg/kg
Administration:	Intravenous injection; 1 mg/kg once per week; for 3 weeks
Result:	Significantly extended survival of KPC mice and showed a better effect than gemcitabine.

体内研究

SOP1812 (1 mg/kg; i.v. once or twice per week for 28 days) shows anti-tumor activity in MIA PaCa-2 xenografts mice and KPC mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic nude mice with MIA PaCa-2 xenografts
Dosage:	1 mg/kg
Administration:	Intravenous injection; 1 mg/kg once or twice per week; for 28 days
Result:	Showed complete tumor regression and no significant tumor regrowth after day 28 on several animals.

Animal Model:	KPC mice with PDAC symptoms
Dosage:	1 mg/kg
Administration:	Intravenous injection; 1 mg/kg once per week; for 3 weeks
Result:	Significantly extended survival of KPC mice and showed a better effect than gemcitabine.

性状

Solid

溶解性数据

In Vitro:

DMSO : 200 mg/mL (252.53 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.2627 mL	6.3133 mL	12.6266 mL
5 mM	0.2525 mL	1.2627 mL	2.5253 mL
10 mM	0.1263 mL	0.6313 mL	1.2627 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式