IMR-1A|cas:331862-41-0|西域试剂

IMR-1A,98.23%

产品编号：Bellancom-100431A| CAS NO：331862-41-0| 分子式：C₁₃H₁₁NO₅S₂| 分子量：325.36

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货号	价格	库存与货期
Bellancom-100431A	￥3000.00	杭州北京（现货）
Bellancom-100431A	￥4500.00	杭州北京（现货）
Bellancom-100431A	￥12000.00	杭州北京（现货）
Bellancom-100431A	￥17000.00	杭州北京（现货）

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IMR-1A

产品介绍

IMR-1A 是 IMR-1 的酸代谢物，一种有效的 Notch 抑制剂，IC₅₀ 为 0.5 μM。IMR-1A 相对于 IMR-1 的效力增加了 50 倍。IMR-1 在体内可以代谢为 IMR-1A。

生物活性

IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC₅₀ of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A.

体外研究

体内研究

IMR-1A (2 mg/kg (i.v.) and 100 mg/kg (i.p)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57 BL/6 mice
Dosage:	2 mg/kg (i.v.) and 100 mg/kg (i.p)
Administration:	I.v. and i.p.
Result:	Exhibited low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration and plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57 BL/6 mice
Dosage:	2 mg/kg (i.v.) and 100 mg/kg (i.p)
Administration:	I.v. and i.p.
Result:	Exhibited low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration and plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration.

性状

Solid

溶解性数据

In Vitro:

DMSO : 2 mg/mL (6.15 mM; Need ultrasonic)

H₂O : 1 mg/mL (3.07 mM; ultrasonic and warming and heat to 80°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0735 mL	15.3676 mL	30.7352 mL
5 mM	0.6147 mL	3.0735 mL	6.1470 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式