KIF18A-IN-3|cas:2600577-49-7|西域试剂

KIF18A-IN-3,99.18%

产品编号：Bellancom-145803| CAS NO：2600577-49-7| 分子式：C₂₈H₃₈N₄O₅S₂| 分子量：574.76

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-145803		￥7400.00	杭州北京（现货）
Bellancom-145803		￥11700.00	杭州北京（现货）

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KIF18A-IN-3

产品介绍

KIF18A-IN-3 是一种有效的 KIF18A 抑制剂 (IC₅₀=61 nM)。KIF18A-IN-3 能引起明显的有丝分裂停滞，增加肿瘤组织中有丝分裂细胞的数量。KIF18A-IN-3 可用于肿瘤研究。

生物活性

KIF18A-IN-3 is a potent KIF18A inhibitor (IC₅₀=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer.

体外研究

体内研究

KIF18A-IN-3 (compound 24) exhibits a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours. Pharmacokinetic Parameters of KIF18A-IN-3 in female CD-1 mice.

	IP (100 mg/kg)
C_max (μM)	26.5
AUC_0-24 (μM·h)	269
C_24h (μM)	0.8
PPB (f_u)	0.015

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic nude mice (4-7 weeks; injected with human OVCAR-3 HGSOC cells)
Dosage:	100 mg/kg
Administration:	i.p., single
Result:	Showed a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.

体内研究

	IP (100 mg/kg)
C_max (μM)	26.5
AUC_0-24 (μM·h)	269
C_24h (μM)	0.8
PPB (f_u)	0.015

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic nude mice (4-7 weeks; injected with human OVCAR-3 HGSOC cells)
Dosage:	100 mg/kg
Administration:	i.p., single
Result:	Showed a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.