EW-7195|cas:1352609-28-9|西域试剂

EW-7195,99.20%

产品编号：Bellancom-18766| CAS NO：1352609-28-9| 分子式：C₂₃H₁₈N₈| 分子量：406.44

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货号	价格	库存与货期
Bellancom-18766	￥4000.00	杭州北京（现货）
Bellancom-18766	￥6800.00	杭州北京（现货）
Bellancom-18766	￥13500.00	杭州北京（现货）

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EW-7195

产品介绍

EW-7195 是一种有效的、选择性 ALK5 (TGFβR1) 抑制剂，IC₅₀ 为 4.83 nM。EW-7195 对 ALK5 的选择性是 p38α 的 300 多倍。EW-7195 能有效抑制 TGF-β1 诱导的 Smad 信号转导、上皮间质转化 (EMT) 和乳腺癌向肺转移。

生物活性

EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor with an IC₅₀ of 4.83 nM. EW-7195 has >300-fold selectivity for ALK5 over p38α. EW-7195 efficiently inhibits TGF-β1-induced Smad signaling, epithelial-to-mesenchymal transition (EMT) and breast tumour metastasis to the lung.

体外研究

EW7195 inhibits the EMT, motility, and invasiveness of breast cancer cells in vitro. EW-7195 efficiently blocks TGF-β1-induced phosphorylation of Smad2 followed by the nuclear translocation of Smad2/3. EW-7195 blocks TGF-β1-induced mesenchymal morphology. EW-7195 inhibits TGF-β-induced transcriptional activation.
EW-7195 (0.5-1 µM; 1.5 hours) efficiently inhibits TGF-β1-induced Smad2 phosphorylation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

EW7195 (40 mg/kg; i.p.; three times a week for 3/2.5 weeks) inhibits lung metastasis development in both 4T1 orthotopic xenograft and MMTV/cNeu transgenic mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MMTV/c-Neu mice
Dosage:	40 mg/kg
Administration:	I.p.; three times a week for 3 weeks
Result:	Inhibited the metastasis of breast cancer cells to the lung.

Animal Model:	Balb/c xenograft model (10-weeks-old female Balb/c mice bearing 4T1 cells)
Dosage:	40 mg/kg
Administration:	I.p.; three times a week for 2.5 weeks
Result:	Suppressed a lung metastasis in the Balb/c Xenograft model.

体内研究

EW7195 (40 mg/kg; i.p.; three times a week for 3/2.5 weeks) inhibits lung metastasis development in both 4T1 orthotopic xenograft and MMTV/cNeu transgenic mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MMTV/c-Neu mice
Dosage:	40 mg/kg
Administration:	I.p.; three times a week for 3 weeks
Result:	Inhibited the metastasis of breast cancer cells to the lung.

Animal Model:	Balb/c xenograft model (10-weeks-old female Balb/c mice bearing 4T1 cells)
Dosage:	40 mg/kg
Administration:	I.p.; three times a week for 2.5 weeks
Result:	Suppressed a lung metastasis in the Balb/c Xenograft model.

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (123.02 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4604 mL	12.3019 mL	24.6039 mL
5 mM	0.4921 mL	2.4604 mL	4.9208 mL
10 mM	0.2460 mL	1.2302 mL	2.4604 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式