ZINC69391|cas:303094-67-9|西域试剂

ZINC69391,99.77%

产品编号：Bellancom-102078| CAS NO：303094-67-9| 分子式：C₁₄H₁₄F₃N₅| 分子量：309.29

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货号	价格	库存与货期
Bellancom-102078	￥2600.00	杭州北京（现货）
Bellancom-102078	￥4200.00	杭州北京（现货）
Bellancom-102078	￥8400.00	杭州北京（现货）
Bellancom-102078	￥13000.00	杭州北京（现货）

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ZINC69391

产品介绍

ZINC69391 是一种特异的 Rac1 抑制剂，通过在 Rac1 表面掩蔽 Trp56 残基来干扰 Rac1-GEF 的相互作用。ZINC69391 干扰 Rac1 与 Dock180 的相互作用，降低 Rac1-GTP水平。ZINC69391 诱导细胞凋亡，具有抗增殖和抗转移作用。

生物活性

ZINC69391, a specific Rac1 inhibitor, interferes with Rac1-GEF interaction by masking Trp56 residue on Rac1 surface. ZINC69391 interferes with the interaction of Rac1 with Dock180 and reduces Rac1-GTP levels. ZINC69391 induces apoptosis, and shows antiproliferative and antimetastatic effects.

体外研究

ZINC69391 inhibits growth of U937, HL-60, KG1A and Jurkat cells with IC₅₀s ranging from 41 to 54 μM.
ZINC69391 (50-100 μM; 24 hours) augments the enzymatic activity of caspase 3 in a concentration dependent manner.
ZINC69391 (0-125 μM; 72h) reduces cell proliferation of human glioma cells.
ZINC69391 (50-100 μM; 48 hours) triggers cell cycle arrest.
ZINC69391 (50 μM; 24 hours) triggers apoptosis on human acute leukemic cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	U-87 MG, LN229 cells
Concentration:	0-125μM
Incubation Time:	72 hours
Result:	Reduced cell proliferation in a concentration-dependent manner.

Cell Cycle Analysis

Cell Line:	LN229 cells
Concentration:	50, 100 μM
Incubation Time:	48 hours
Result:	Resulted in a significant increased percentage of cells in the sub-G0/G1 phase in a concentration dependent manner.

Apoptosis Analysis

Cell Line:	HL-60, U937 and KG1A cell lines
Concentration:	50 μM
Incubation Time:	24 hours
Result:	Led to a significant increase in apoptotic cells.

体内研究
(In Vivo)

ZINC69391 (25 mg/kg; i.p; daily for 21 days) impairs metastatic lung colonization in a syngeneic animal model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Specific pathogen-free female BALB/c inbred mice (bearing F3II cells)
Dosage:	25 mg/kg body weight
Administration:	I.p; daily for 21 days
Result:	Significantly reduced by about 60% the formation of total metastatic lung colonies.

体内研究

ZINC69391 (25 mg/kg; i.p; daily for 21 days) impairs metastatic lung colonization in a syngeneic animal model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Specific pathogen-free female BALB/c inbred mice (bearing F3II cells)
Dosage:	25 mg/kg body weight
Administration:	I.p; daily for 21 days
Result:	Significantly reduced by about 60% the formation of total metastatic lung colonies.

体内研究

ZINC69391 (25 mg/kg; i.p; daily for 21 days) impairs metastatic lung colonization in a syngeneic animal model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Specific pathogen-free female BALB/c inbred mice (bearing F3II cells)
Dosage:	25 mg/kg body weight
Administration:	I.p; daily for 21 days
Result:	Significantly reduced by about 60% the formation of total metastatic lung colonies.

性状

Solid

溶解性数据

In Vitro:

DMSO : 25 mg/mL (80.83 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.2332 mL	16.1661 mL	32.3321 mL
5 mM	0.6466 mL	3.2332 mL	6.4664 mL
10 mM	0.3233 mL	1.6166 mL	3.2332 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式