tans-4-Hydroxy-D-proline hydrochloride|cas:142347-81-7|西域试剂

tans-4-Hydroxy-D-proline hydrochloride,97.0%

产品编号：Bellancom-W003511| CAS NO：142347-81-7| 分子式：C₅H₁₀ClNO₃| 分子量：167.59

tans-4-羟基-D-脯氨酸盐酸盐是一种不可切割的ADC连接物，用于合成抗体药物结合物（ADC）。tans-4-羟基-D-脯氨酸盐酸盐也是一种基于烷基链的PROTAC连接剂，可用于合成PR

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-W003511		￥200.00	杭州北京（现货）
Bellancom-W003511		￥350.00	杭州北京（现货）

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tans-4-Hydroxy-D-proline hydrochloride

产品介绍

tans-4-Hydroxy-D-proline hydrochloride是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联活性分子 (ADCs)。tans-4-Hydroxy-D-proline hydrochloride 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

生物活性

tans-4-Hydroxy-D-proline hydrochloride is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PR

体外研究

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [Content Brief]

. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]

化学品安全说明书(MSDS)

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产品编号(Item Number)

批号(Lot Number)

上游产品 1
135042-17-0
下游产品 2
481704-21-6 139262-20-7

tans-4-Hydroxy-D-proline hydrochloride,97.0%

tans-4-Hydroxy-D-proline hydrochloride

化学品安全说明书(MSDS)

质检证书(COA)

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