UAMC00039 dihydrochloride|cas:697797-51-6|西域试剂

UAMC00039 dihydrochloride,99.81%

产品编号：Bellancom-101769| CAS NO：697797-51-6| 分子式：C₁₆H₂₆Cl₃N₃O| 分子量：382.76

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-101769	￥800.00	杭州北京（现货）
Bellancom-101769	￥1200.00	杭州北京（现货）
Bellancom-101769	￥1800.00	杭州北京（现货）
Bellancom-101769	￥4000.00	杭州北京（现货）
Bellancom-101769	￥7200.00	杭州北京（现货）

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UAMC00039 dihydrochloride

产品介绍

UAMC00039 dihydrochloride是高效，可逆，竞争性的dipeptidyl peptidase II抑制剂，IC₅₀值为0.48 nM。

生物活性

UAMC00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase II inhibitor with an IC₅₀ of 0.48 nM.

体外研究

UAMC00039 has an IC₅₀ of 0.48±0.04 nM and a high selectivity for DPPII compared to DPPIV (IC₅₀=165±9 µM) and DPP activity not caused by DPPII or DPPIV. UAMC00039 seems a promising tool to unravel the function of DPPII as well as to validate its potential as a therapeutic target. The efficacy of a DPPII inhibitor in cell culture depends not only on the inhibitors’ potency towards the enzyme but also on its stability in the medium and its ability to enter the cell. UAMC00039 is stable for at least 48 h at 37 °C in culture medium and in DPPII assay buffer. The compound is able to enter PBMC within 1 min resulting in a concentration-dependent inhibition of intracellular DPPII activity without affecting the ‘non-DPPII’ DPP activity. 1 and 100 μM UAMC00039 inhibits DPPII activity of PBMC and U937 cells more than 90%.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

A dose dependent inhibition of DPPII but not of DPPIV is observed in the peripheral organs of both the rats and the mice (after oral administration) and the rabbits (after IV administration). UAMC00039 tested orally at 2 mg/kg does not cause signs of acute toxicity and does not cause any significant changes in the following functions that are evaluated: general behaviour, body temperature, respiration, bleeding time, blood pressure, urine volume, liver function, fasting glucose and gastrointestinal parameters like acidity, motility and irritation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 150 mg/mL (391.89 mM)

H₂O : 100 mg/mL (261.26 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.6126 mL	13.0630 mL	26.1260 mL
5 mM	0.5225 mL	2.6126 mL	5.2252 mL
10 mM	0.2613 mL	1.3063 mL	2.6126 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶