Camptothecin-20(S)-O-propionate Camptothecin-20-O-propionate|cas:194414-69-2|西域试剂

Camptothecin-20(S)-O-propionate Camptothecin-20-O-propionate,99.55%

产品编号：Bellancom-114668| CAS NO：194414-69-2| 分子式：C₂₃H₂₀N₂O₅| 分子量：404.42

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货号	价格	库存与货期
Bellancom-114668	￥3500.00	杭州北京（现货）
Bellancom-114668	￥5800.00	杭州北京（现货）
Bellancom-114668	￥16500.00	杭州北京（现货）
Bellancom-114668	￥25500.00	杭州北京（现货）

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Camptothecin-20(S)-O-propionate Camptothecin-20-O-propionate

产品介绍

Camptothecin-20(S)-O-propionate (CZ48) 是喜树碱 (CPT) 的类似物，是强效的抗肿瘤化合物。Camptothecin-20(S)-O-propionate (CZ48) 是拓扑异构酶 I(topoisomerase-Ι) 的抑制剂。

生物活性

Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor.

体外研究

体内研究

Camptothecin-20(S)-O-propionate (CZ48, gavage, 100 to 2000 mg/kg/day) exhibits anti-tumor activity in CLO-breast carcinoma (100 mg/kg) and PC3-prostate carcinoma (1000 mg/kg) models in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	A tumor xenograft growing in a nude mouse (size, ∼1 cm³).
Dosage:	100-1000 mg/kg/day.
Administration:	Oral gavage, for 2, 4 and 6 days, respectively.
Result:	Exhibited anti-tumor effect.

体内研究

Camptothecin-20(S)-O-propionate (CZ48, gavage, 100 to 2000 mg/kg/day) exhibits anti-tumor activity in CLO-breast carcinoma (100 mg/kg) and PC3-prostate carcinoma (1000 mg/kg) models in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	A tumor xenograft growing in a nude mouse (size, ∼1 cm³).
Dosage:	100-1000 mg/kg/day.
Administration:	Oral gavage, for 2, 4 and 6 days, respectively.
Result:	Exhibited anti-tumor effect.

性状

Solid

溶解性数据

In Vitro:

DMSO : 9.09 mg/mL (22.48 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4727 mL	12.3634 mL	24.7268 mL
5 mM	0.4945 mL	2.4727 mL	4.9454 mL
10 mM	0.2473 mL	1.2363 mL	2.4727 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式