PKUMDL-WQ-2101|cas:304481-72-9|西域试剂

PKUMDL-WQ-2101,99.85%

产品编号：Bellancom-123269| CAS NO：304481-72-9| 分子式：C₁₄H₁₁N₃O₆| 分子量：317.25

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货号	价格	库存与货期
Bellancom-123269	￥500.00	杭州北京（现货）
Bellancom-123269	￥800.00	杭州北京（现货）
Bellancom-123269	￥1700.00	杭州北京（现货）
Bellancom-123269	￥2900.00	杭州北京（现货）
Bellancom-123269	￥5000.00	杭州北京（现货）

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PKUMDL-WQ-2101

产品介绍

PKUMDL-WQ-2101 是一种非 NAD⁺ 竞争性变构磷酸甘油酸脱氢酶 (PHGDH) 抑制剂，IC₅₀ 为 34.8 μM。PKUMDL-WQ-2101 具有抗肿瘤活性。

生物活性

PKUMDL-WQ-2101 is a non-NAD⁺-competing allosteric phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC₅₀ of 34.8 μM. PKUMDL-WQ-2101 exhibits antitumor activity.

体外研究

PKUMDL-WQ-2101（72 小时）在微摩尔浓度下显示出对细胞活力的剂量依赖性抑制作用，对 PHGDH 扩增的乳腺癌细胞系具有良好的选择性。PKUMDL-WQ-2101 在两种 PHGDH 扩增的乳腺癌细胞系（MDA-MB-468 和 HCC70）中的抗肿瘤活性分别为 7.70 μM 和 10.8 μM。
PKUMDL-WQ-2101（2.5-40 μM；24 小时）导致 MDA-MB-468 细胞的细胞周期停滞。
PKUMDL-WQ-2101（37 μM；24 小时）减少丝氨酸合成途径下游的丝氨酸从头合成和代谢，其作用与 PHGDH 基因缺失相当。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	MDA-MB-468 cells
Concentration:	2.5 μM, 5.0 μM, 20 μM and 40 μM
Incubation Time:	24 hours
Result:	Caused cell cycle arrest.

体内研究
(In Vivo)

PKUMDL-WQ-2101（5-20 mg/kg；i.p；每天；持续 30 天）对 MDA-MB-468 异种移植物表现出显着的抑制作用。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NOD.CB17 Scid/J mice injected with MDA-MB-468 cells
Dosage:	5 mg/kg, 10 mg/kg, 20 mg/kg
Administration:	i.p; daily; for 30 days
Result:	Exhibited substantial inhibitory effects on MDA-MB-468 xenografts.

体内研究

PKUMDL-WQ-2101（5-20 mg/kg；i.p；每天；持续 30 天）对 MDA-MB-468 异种移植物表现出显着的抑制作用。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NOD.CB17 Scid/J mice injected with MDA-MB-468 cells
Dosage:	5 mg/kg, 10 mg/kg, 20 mg/kg
Administration:	i.p; daily; for 30 days
Result:	Exhibited substantial inhibitory effects on MDA-MB-468 xenografts.

体内研究

PKUMDL-WQ-2101（5-20 mg/kg；i.p；每天；持续 30 天）对 MDA-MB-468 异种移植物表现出显着的抑制作用。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NOD.CB17 Scid/J mice injected with MDA-MB-468 cells
Dosage:	5 mg/kg, 10 mg/kg, 20 mg/kg
Administration:	i.p; daily; for 30 days
Result:	Exhibited substantial inhibitory effects on MDA-MB-468 xenografts.