LEQ506 NVP-LEQ506|cas:1204975-42-7|西域试剂

LEQ506 NVP-LEQ506,98.0%

产品编号：Bellancom-18636| CAS NO：1204975-42-7| 分子式：C₂₅H₃₂N₆O| 分子量：432.56

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-18636		￥5000.00	杭州北京（现货）
Bellancom-18636		￥8500.00	杭州北京（现货）

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LEQ506 NVP-LEQ506

产品介绍

LEQ506 是第二代 smoothened (smo) 抑制剂，在人类和小鼠中的 IC₅₀ 值分别为 2 和 4 nM。

生物活性

LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC₅₀s of 2 and 4 nM in human and mouse, respectively.

体外研究

LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC₅₀s of 2 and 4 nM in human and mouse, respectively. LEQ506 inhibits Hedgehog (Hh) signaling in a human cell line (HEPM) as measured by the amount of Gli mRNA with an IC₅₀ ~6-fold lower than that of Compound 2. LEQ506 is an efficacious compound by consistently decreasing Gli1 mRNA by about 70 to 80%. LEQ506 shows a tendency to preferentially inhibit Gli1 rather than Ptch1 mRNA. LEQ506 (at 1%) is also an efficacious compound with an inhibition of 80 to 90% for Gli1 and of 60 to 70% for Ptch1.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (231.18 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3118 mL	11.5591 mL	23.1182 mL
5 mM	0.4624 mL	2.3118 mL	4.6236 mL
10 mM	0.2312 mL	1.1559 mL	2.3118 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式