BRK inhibitor P21d hydrochloride is a potent breast tumor kinase (BRK/PTK6) inhibitor with an IC₅₀ of 30 nM. BRK inhibitor P21d hydrochloride inhibits p-SAM68 with an IC₅₀ of 52 nM. BRK inhibitor P21d hydrochloride can be used to evaluate the in vivo activity of BRK inhibitors in xenograft breast tumor models.

BRK inhibitor P21d hydrochloride (compound 21d) inhibits Aurora B (IC₅₀>20 μM) and Lck (IC₅₀>20 μM).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

BRK inhibitor P21d hydrochloride (compound 21d) has much better permeability (CACO-2:314 nm/s) and PK profile (rat, po, 10 mpk, AUC_0–6h=31.1 μM•h,C_6h=3.5 μM).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

BRK inhibitor P21d hydrochloride (compound 21d) has much better permeability (CACO-2:314 nm/s) and PK profile (rat, po, 10 mpk, AUC_0–6h=31.1 μM•h,C_6h=3.5 μM).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Hongbo Zeng, et al. Discovery of Novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 Inhibitors. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5870-5.  [Content Brief]