Trastuzumab emtansine 曲妥珠单抗-美坦新偶联物; Ado-Trastuzumab emtansine; PRO132365; T-DM 1|cas:1018448-65-1|西域试剂

Trastuzumab emtansine 曲妥珠单抗-美坦新偶联物; Ado-Trastuzumab emtansine; PRO132365; T-DM 1,99.40%

产品编号：Bellancom-P9921| CAS NO：1018448-65-1| 分子式：C₆₄₄₈H₉₉₄₈N₁₇₂₀O₂₀₁₂S₄₄·(C₄₇H₆₂ClN₄O₁₃S)n| 分子量：

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货号	价格	库存与货期
Bellancom-P9921	￥4800.00	杭州北京（现货）
Bellancom-P9921	￥16000.00	杭州北京（现货）
Bellancom-P9921	￥26000.00	杭州北京（现货）

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Trastuzumab emtansine 曲妥珠单抗-美坦新偶联物; Ado-Trastuzumab emtansine; PRO132365; T-DM 1

产品介绍

Trastuzumab emtansine (Ado-Trastuzumab emtansine) 是一种抗体偶联活性分子 (ADC)，其结合了 HER2 靶向的曲妥珠单抗的抗肿瘤特性以及微管抑制剂 DM1 的细胞毒活性。Trastuzumab emtansine 可用于晚期乳腺癌的研究。

生物活性

Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine). Trastuzumab emtansine can be used for the research of advanced breast cancer.

体外研究

Trastuzumab emtansine (2 μg/mL; 3 d) significantly inhibits the proliferation of epithelial ovarian cancer (EOC) cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Trastuzumab emtansine (15 mg/kg; i.v. three to five times weekly for 3 weeks) exhibits significantly anti-tumor effect in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CB-17/SCID mice (6 weeks) were injected with OVA10 cells
Dosage:	15 mg/kg
Administration:	I.v. three to five times weekly for 3 weeks
Result:	Showed remarkable inhibition of tumor growth in mice and was well tolerated.

体内研究

Trastuzumab emtansine (15 mg/kg; i.v. three to five times weekly for 3 weeks) exhibits significantly anti-tumor effect in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CB-17/SCID mice (6 weeks) were injected with OVA10 cells
Dosage:	15 mg/kg
Administration:	I.v. three to five times weekly for 3 weeks
Result:	Showed remarkable inhibition of tumor growth in mice and was well tolerated.

性状

Solid

溶解性数据

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Store at 4°C, do not freeze

参考文献

. Verma S, et, al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med. 2012 Nov 8;367(19):1783-91. [Content Brief]

. Menderes G, et, al. Superior in vitro and in vivo activity of trastuzumab-emtansine (T-DM1) in comparison to trastuzumab, pertuzumab and their combination in epithelial ovarian carcinoma with high HER2/neu expression. Gynecol Oncol. 2017 Oct;147(1):145-152. [Content Brief]

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Trastuzumab emtansine 曲妥珠单抗-美坦新偶联物; Ado-Trastuzumab emtansine; PRO132365; T-DM 1,99.40%

Trastuzumab emtansine 曲妥珠单抗-美坦新偶联物; Ado-Trastuzumab emtansine; PRO132365; T-DM 1

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