Atuveciclib S-Enantiomer BAY-1143572 S-Enantiomer|cas:2250279-81-1|西域试剂

Atuveciclib S-Enantiomer BAY-1143572 S-Enantiomer,99.38%

产品编号：Bellancom-12871C| CAS NO：2250279-81-1| 分子式：C₁₈H₁₈FN₅O₂S| 分子量：387.43

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-12871C		￥5500.00	杭州北京（现货）
Bellancom-12871C		￥8500.00	杭州北京（现货）

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Atuveciclib S-Enantiomer BAY-1143572 S-Enantiomer

产品介绍

Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) 是一种有效的选择性 CDK9 抑制剂，抑制 CDK9/CycT1，IC₅₀ 为 16 nM。

生物活性

Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is a potent and selective CDK9 inhibitor, which inhibits CDK9/CycT1 with an IC₅₀ of 16 nM.

体外研究

In comparison with Atuveciclib (BAY-1143572), Atuveciclib (BAY-1143572) S-Enantiomer reveals very similar in vitro properties, well within the limits of measurement accuracy; however, with multiple batches of Atuveciclib (BAY-1143572) S-Enantiomer there is a trend toward a slightly lower activity against CDK9 in the biochemical assay (IC₅₀ CDK9/CycT1: 16 nM) and antiproliferative activity against HeLa cells (IC₅₀: 1100 nM) .

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Atuveciclib (BAY-1143572) S-Enantiomer exhibits blood/plasma ratios of about 1. Relative to Atuveciclib (BAY-1143572), Atuveciclib (BAY-1143572) S-Enantiomer reveals very similar rat PK properties in vivo (CL_b: 1.2 L/kg per hour, V_ss: 1.2 L/kg, t_1/2: 0.6 h, F: 53 %).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 113 mg/mL (291.67 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5811 mL	12.9056 mL	25.8111 mL
5 mM	0.5162 mL	2.5811 mL	5.1622 mL
10 mM	0.2581 mL	1.2906 mL	2.5811 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式