PROTAC HSP90 degrader BP3|cas:2669072-88-0|西域试剂

PROTAC HSP90 degrader BP3,98.56%

产品编号：Bellancom-115997| CAS NO：2669072-88-0| 分子式：C₃₂H₂₉ClN₈O₅| 分子量：641.08

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-115997		￥6500.00	杭州北京（现货）
Bellancom-115997		￥10200.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

PROTAC HSP90 degrader BP3

产品介绍

PROTAC HSP90 degrader BP3 以 CRBN 依赖性方式有效且选择性地降解 HSP90。PROTAC HSP90 degrader BP3对 MCF-7 细胞中的 HSP90 蛋白有一定的降解作用 (DC₅₀=0.99 µM)。PROTAC HSP90 degrader BP3 抑制乳腺癌细胞的生长。

生物活性

PROTAC HSP90 degrader BP3 is a potent and selective degradation of HSP90 in a CRBN-dependent fashion. PROTAC HSP90 degrader BP3 has a certain certain degradation effect on HSP90 protein in MCF-7 cells (DC₅₀=0.99 µM). PROTAC HSP90 degrader BP3 inhibits the growth of breast cancer cell.

体外研究

PROTAC HSP90 degrader BP3 (compound 16b) (72 h) inhibits the growth of breast cancer cells (IC₅₀=0.63 µM in MCF-7 cells, IC₅₀=3.53 µM in MDA-MB-231 cells, IC₅₀=0.61 µM in 4T1 cells, IC₅₀=2.95 µM in MDA-MB-468 cells).
PROTAC HSP90 degrader BP3 (2 µM; 6 h) shows degradation activity in the MCF-7 cells (DC₅₀=0.99 µM).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	MCF-7 cells
Concentration:	2 µM
Incubation Time:	6 h
Result:	Showed degradation activity in the MCF-7 cells (DC₅₀=0.99 µM).

Cell Viability Assay

Cell Line:	4T1, MDA-MB-468 cells
Concentration:	0.01, 1, 100, 10000 µM
Incubation Time:	72 h
Result:	Inhibited the growth of cancer cells (IC₅₀=0.61 µM in 4T1 cells, IC₅₀=2.95 µM in MDA-MB-468 cells).

体内研究
(In Vivo)

PROTAC HSP90 degrader BP3 (40 mg/kg; i.p., daily for 12 days) inhibits tumor growth and the tumor inhibition rate is 76.41%.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6- to 8-week-old female BALB/c mice
Dosage:	40 mg/kg
Administration:	i.p., daily, 12 days
Result:	Inhibited tumor growth and the tumor inhibition rate was 76.41%.

体内研究

PROTAC HSP90 degrader BP3 (40 mg/kg; i.p., daily for 12 days) inhibits tumor growth and the tumor inhibition rate is 76.41%.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6- to 8-week-old female BALB/c mice
Dosage:	40 mg/kg
Administration:	i.p., daily, 12 days
Result:	Inhibited tumor growth and the tumor inhibition rate was 76.41%.

体内研究

PROTAC HSP90 degrader BP3 (40 mg/kg; i.p., daily for 12 days) inhibits tumor growth and the tumor inhibition rate is 76.41%.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6- to 8-week-old female BALB/c mice
Dosage:	40 mg/kg
Administration:	i.p., daily, 12 days
Result:	Inhibited tumor growth and the tumor inhibition rate was 76.41%.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (155.99 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5599 mL	7.7993 mL	15.5987 mL
5 mM	0.3120 mL	1.5599 mL	3.1197 mL
10 mM	0.1560 mL	0.7799 mL	1.5599 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式