Masofaniten Androgen receptor-IN-2|cas:2416716-62-4|西域试剂

Masofaniten Androgen receptor-IN-2,98.28%

产品编号：Bellancom-136582| CAS NO：2416716-62-4| 分子式：C₂₄H₂₄Cl₂N₄O₄S| 分子量：535.44

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货号	价格	库存与货期
Bellancom-136582	￥4050.00	杭州北京（现货）
Bellancom-136582	￥7200.00	杭州北京（现货）
Bellancom-136582	￥14850.00	杭州北京（现货）

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Masofaniten Androgen receptor-IN-2

产品介绍

Masofaniten (Androgen receptor-IN-2) 是一种有效的、具有口服活性的 androgen receptor 抑制剂。Masofaniten 对前列腺癌具有抗肿瘤活性。

生物活性

Masofaniten (Androgen receptor-IN-2) is a potent and orally active androgen receptor inhibitor. Masofaniten has antitumor activity against prostate cancer.

体外研究

Masofaniten (compound A109, androgen-induced PSA-Luciferase assay) inhibits androgen binding to androgen receptor with an IC₅₀ of 535 nM.
Masofaniten inhibits cell proliferation in LNCaP and LNCaP95 cells (IC₅₀: 0.44 μM, 3.78 μM respectively).
Masofaniten shows a metabolic stability in liver microsome with a t_1/2 of more than 120 min, and in hepatocytes with a t_1/2 of more than 360 min.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Masofaniten (compound A109) (60 mg/kg, p.o.) induces partial regressions of tumor growth in NCG mice bearing LNCaP tumors.
Masofaniten (5 mg/kg, p.o., single dose, in male CD-1 mice) shows a t_1/2 of 8.1 h, C_max of 2673.3 ng/mL, F (%) of 33.6.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	LNCaP Xenografts Model
Dosage:	60 mg/kg
Administration:	Oral administration (p.o.)
Result:	Inhibited tumor growth no obvious drug related toxicity (bodyweight change).

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	LNCaP Xenografts Model
Dosage:	60 mg/kg
Administration:	Oral administration (p.o.)
Result:	Inhibited tumor growth no obvious drug related toxicity (bodyweight change).

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (93.38 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8676 mL	9.3381 mL	18.6762 mL
5 mM	0.3735 mL	1.8676 mL	3.7352 mL
10 mM	0.1868 mL	0.9338 mL	1.8676 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式