AZD3229 Tosylate|cas:2248003-71-4|西域试剂

AZD3229 Tosylate,99.80%

产品编号：Bellancom-112802A| CAS NO：2248003-71-4| 分子式：C₃₁H₃₄FN₇O₆S| 分子量：651.71

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-112802A	￥1850.00	杭州北京（现货）
Bellancom-112802A	￥2900.00	杭州北京（现货）
Bellancom-112802A	￥5300.00	杭州北京（现货）
Bellancom-112802A	￥8800.00	杭州北京（现货）
Bellancom-112802A	￥14800.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

AZD3229 Tosylate

产品介绍

AZD3229 Tosylate 是一种有效的、广泛的突变型酪氨酸激酶受体 (KIT) 抑制剂，可用于开发研究胃肠道间质瘤。

生物活性

AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.

体外研究

AZD3229 is a potent, pan-KIT mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI₅₀=1-50 nM). AZD3229 demonstrates potent single digit nM growth inhibition across a broad cell panel, with good margin to KDR-driven effects. Selectivity over KDR can be rationalised predominantly by the interaction of water molecules with the protein and ligand in the active site and its kinome selectivity is similar to the best of the approved GIST agents.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (153.44 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5344 mL	7.6721 mL	15.3442 mL
5 mM	0.3069 mL	1.5344 mL	3.0688 mL
10 mM	0.1534 mL	0.7672 mL	1.5344 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献